Abstract Body (Do not enter title and authors here): Background: This study focused on exploring the correlation between the electrical and mechanical dyssynchrony of the right ventricle (RV) in pre-capillary pulmonary hypertension (PcPH) patients. It also aimed to compare their predictive capabilities for risk stratification.
Methods: From April 2017 to March 2018, PcPH patients at Fuwai Hospital were consecutively enrolled. They were grouped as low-risk and non-low-risk according to 2015 European Society of Cardiology Guidelines. RV mechanical dyssynchrony (RV-SD6) was measured by off-line software (GE EchoPAC version 201), and QRS duration representing electrical dyssynchrony was manually measured.
Results: Sixty-six PcPH patients (average 35 years, 19 males and 47 females) were finally enrolled, 37 in low-risk group, while 29 in non-low-risk group. QRS duration was significantly correlated with RV-SD6 (r = 0.25, P = 0.047). Both RV-SD6 and QRS duration significantly correlated with N-terminal pro-brain natriuretic peptide (r = 0.44, P＜0.001 vs r = 0.26, P = 0.039). Furthermore, RV-SD6 (area under curve, AUC 0.75, 95% confidence interval, CI 0.64–0.87, P ＜ 0.001) and QRS duration (AUC 0.65, 95% CI 0.52–0.78, P = 0.036) both had the potential to predict non-low risk stratification. Multivariate Logistic regression analyses identified RV-SD6 (OR: 1.02, 95% CI: 1.01–1.03, P = 0.009) and QRS duration (odds ratio, OR: 1.07, 95% CI: 1.00–1.15, P = 0.045) as independent predictors of non-low risk of PcPH patients.
Conclusion: RV-SD6-presented mechanical dyssynchrony correlates with QRS duration and better predicts risk stratification in PcPH patients without complete bundle branch block.