Logo

American Heart Association

  18
  0


Final ID: EPI11

Actigraphy-Measured Sleep Irregularity Increases the Risk of Incident Cardiovascular Disease and Cardiovascular Mortality in Older Women

Abstract Body (Do not enter title and authors here): Background: Cardiovascular disease (CVD) is the leading cause of death for U.S. women. Our understanding of the link between poor sleep health and CVD remains limited by reliance on cross-sectional study designs, self-reported sleep measures, and predominately non-Hispanic white participants. Our objective was to investigate associations between actigraphy-measured sleep health and incident CVD and CVD mortality in a cohort of older multiethnic women.

Methods: Women (n=3,992; mean age: 78.5 years, 33% African American, 17% Hispanic/Latino) enrolled in the Women’s Health Initiative OPACH (Objective Physical Activity and Cardiovascular Health) study wore an Actigraph GT3X+ accelerometer for 7 days in May 2012-April 2014 and were followed through February 2022 for physician-adjudicated incident CVD (myocardial infarction, stroke, or death due to CVD) and CVD mortality. Sleep duration, timing, efficiency, irregularity, and continuity were derived from accelerometers (see Table footnote). Women with a history of prior CVD at the time of accelerometer wear were excluded. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Minimally adjusted models included age, race, and ethnicity. Models were additionally adjusted for education, smoking status, alcohol use, comorbid conditions, self-rated health, and CVD risk factors including hypertension, body mass index, systolic blood pressure, cholesterol, and glucose.

Results: Over a median of 8.3 years of follow-up, 636 incident CVD cases occurred, including 395 CVD deaths. In minimally adjusted models, longer sleep duration, greater sleep irregularity, and more wake after sleep onset were associated with increased CVD risk (Table 1). In models further adjusted for CVD risk factors, the HR (95% CI) for a 60-minute increase in sleep irregularity was 1.18 (1.01-1.37) for incident CVD and 1.30 (1.07-1.58) for CVD mortality.

Conclusions: Greater sleep irregularity was associated with higher risk of incident CVD and CVD mortality in a cohort of older women. These results support the importance of maintaining regular sleep for cardiovascular health.
  • Full, Kelsie  ( Vanderbilt University Medical Cntr , Nashville , Tennessee , United States )
  • Nguyen, Steven  ( University of California, San Diego , San Diego , California , United States )
  • Lamonte, Michael  ( University at Buffalo , Buffalo , New York , United States )
  • Lacroix, Andrea  ( University of California, San Diego , San Diego , California , United States )
  • Author Disclosures:
    Kelsie Full: DO NOT have relevant financial relationships | Steven Nguyen: DO NOT have relevant financial relationships | Michael LaMonte: DO NOT have relevant financial relationships | Andrea LaCroix: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Best of AHA Specialty Conferences: EPI/Lifestyle 2024

Monday, 11/18/2024 , 10:30AM - 11:30AM

Best of Specialty Conferences

More abstracts on this topic:
A Real-world Evaluation of Longitudinal Healthcare Expenses in a Health System Registry of Type-2 Diabetes Mellitus and Cardiovascular Disease Enabled by the 21st Century Cures Act

Dhingra Lovedeep, Aminorroaya Arya, Pedroso Aline, Rajpura Jigar, Mehanna Sherif, Tonnu-mihara Ivy, Khera Rohan

A Measure of Residential Segregation and Thrombo-inflammation in Black and White Americans

Manogaran Erin, Cushman Mary, Kamin Mukaz Debora, Sparks Andrew, Packer Ryan, Brochu Paige, Judd Suzanne, Howard Virginia, Plante Timothy, Long Leann, Cheung Katherine

You have to be authorized to contact abstract author. Please, Login
Not Available