Logo

American Heart Association

  141
  0


Final ID: Sa1010

Acute Myocardial Infarction outcomes in patients on single anticoagulation versus combined anticoagulation and antiplatelet therapy

Abstract Body (Do not enter title and authors here): Introduction:

Current guidelines recommend single anticoagulation (AC) therapy over combined AC plus anti-platelet (AP) therapy in patients with established cardiovascular disease (CVD) and concomitant indication for AC. Data on the in-hospital outcomes of acute myocardial infarction (AMI) in patients on single versus combined therapy is scarce.

Methods:

The National Inpatient Sample was used to identify adult patients with established CVD on AC and a primary diagnosis of AMI between 2016 and 2020. Data was stratified between patients on single AC and patients on combined AC and AP therapy. In-hospital outcomes were compared after case-control matching for significant comorbidities.

Results:

A total of 122,975 patients admitted for AMI were included, of which 57,220 (46.5%) were previously on combined therapy. PCI rates were similar in both groups (34.9% vs 34.6%, P=0.247). After matching (15,140 patients in each group), combined therapy was associated with decreased odds of in-hospital mortality, discharge to skilled nursing facilities (SNF), increased odds of mechanical circulatory support (MCS) use, and similar odds of in-hospital cardiovascular and bleeding complications compared to patients on single AC therapy (Figure 1).

Conclusion:

Combined AC plus AP therapy was associated with decreased in-hospital mortality, increase MCS use, and less SNF discharges compared to patients on single AC therapy admitted for AMI. There was no difference in in-hospital cardiac or bleeding complications.
  • Rosario, Manuel  ( Florida State University , Sarasota , Florida , United States )
  • Vasquez, Moises  ( University of Miami , Miami , Florida , United States )
  • Garcia, Gustavo  ( Florida State University College of medicine at Sarasota Memorial Hospital , Sarasota , Florida , United States )
  • Wojtas, Caroline  ( FSU Sarasota Memorial Hospital , Sarasota , Florida , United States )
  • Vargas, Ian  ( Sarasota Memorial Hospital , Sarasota , Florida , United States )
  • Behers, Benjamin  ( Florida State University , Sarasota , Florida , United States )
  • Author Disclosures:
    Manuel Rosario: DO NOT have relevant financial relationships | Moises Vasquez: No Answer | Gustavo Garcia: DO NOT have relevant financial relationships | Caroline Wojtas: DO NOT have relevant financial relationships | Ian Vargas: DO NOT have relevant financial relationships | Benjamin Behers: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Platelets in Thromboinflammation and Atherosclerosis

Saturday, 11/16/2024 , 10:30AM - 11:30AM

Abstract Poster Session

More abstracts on this topic:
Adherence to Guideline-Directed Oral Anticoagulant Therapy in Patients with Atrial Fibrillation and Atrial Flutter Admitted in a Tertiary Private Hospital: A Retrospective Study

Wong Jasmine, Carandang Frances, Segundo Luigi Pierre

A Polypill Strategy for Lipid Lowering and Anti-Platelet Therapy After Acute Coronary Syndrome: A Pilot Randomized Controlled Trial

Keshvani Neil, Wang Thomas, Pandey Ambarish, Coellar Juan David, Rizvi Syed Kazim, Jain Anand, Bustillo-rubio M. Karina, Segar Matthew, Lokesh Nidhish, Miller James, Yates Sean

You have to be authorized to contact abstract author. Please, Login
Not Available