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American Heart Association

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Final ID: MDP406

Predictors of Clinically Meaningful 1-Year Health Status Improvements Following Endovascular or Surgical Revascularization: Insights from the BEST-CLI Trial

Abstract Body (Do not enter title and authors here): Background: Understanding patient factors associated with successful clinically meaningful health status results after undergoing endovascular or surgical revascularization for chronic limb threatening ischemia (CLTI), will enable targeted allocation of care resources. We examined predictors of meaningful improvements in 1-year health status following endovascular or surgical revascularization 1 year after the procedure.
Methods: We applied distribution-based (0.5 standard deviation of baseline health status scores) minimally clinically important difference (MCID) thresholds to 1-year health status change scores derived from a pooled cohort of the endovascular and surgical arms for the Best Endovascular versus Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial. The trial was conducted during 2014-2019 and enrolled patients with CLTI from 150 international sites. Patients completed the peripheral artery disease (PAD)-specific VascuQol prior randomization and 1 year following randomization. Multivariable logistic regression models (improved vs. remained the same/worsened) for 1-year VascuQol changes were constructed, including demographic and clinical factors. Cubic splines were explored for presenting baseline VascuQol health status scores.
Results: A total of 1,533 patients were included, (71.9% male, mean age 66.9 ± 9.7 years). Absence of diabetes, history of claudication, and lower Wifi stage was more likely to be associated with successful health status response at 1 year (R2=0.77). Baseline presenting health status was associated with the odds of achieving a successful health status response, with those presenting with lower baseline scores (VascuQol score <3), having a higher odds of a successful PAD-specific health status response. Type of revascularization (endo vs. surgery) was not associated with successful health status response (Figure).
Conclusion: Diabetes status, claudication history, and Wifi staging are important factors to evaluate when discussing the potential for a successful health status response following endovascular or surgical revascularization. Overall, those who present with more impacted health status, stand to benefit the most, regardless of revascularization type.
  • Smolderen, Kim  ( Yale University , New Haven , Connecticut , United States )
  • Scierka, Lindsey  ( Yale University , New Haven , Connecticut , United States )
  • Mena-hurtado, Carlos  ( Yale University , New Haven , Connecticut , United States )
  • Menard, Matthew  ( Brigham and Womens Hospital , Boston , Massachusetts , United States )
  • Farber, Alik  ( Boston Medical Center , Boston , Massachusetts , United States )
  • Rosenfield, Kenneth  ( Mass General Hospital , Boston , Massachusetts , United States )
  • Strong, Michael  ( Brigham and Women's Hospital , Lincoln , Massachusetts , United States )
  • Doros, Gheorghe  ( Boston University , Boston , Connecticut , United States )
  • Goodney, Philip  ( DARTMOUTH HITCHCOCK MEDICAL CENTER , Lebanon , New Hampshire , United States )
  • Romain, Gaelle  ( Yale University , Branford , Connecticut , United States )
  • Cleman, Jacob  ( Yale University , New Haven , Connecticut , United States )
  • Author Disclosures:
    Kim Smolderen: DO have relevant financial relationships ; Consultant:Terumo:Active (exists now) ; Consultant:Happify:Active (exists now) ; Research Funding (PI or named investigator):Philips:Active (exists now) ; Research Funding (PI or named investigator):Merck:Active (exists now) ; Research Funding (PI or named investigator):Abbott:Active (exists now) ; Research Funding (PI or named investigator):J&J:Active (exists now) ; Consultant:Cook:Active (exists now) | Lindsey Scierka: DO NOT have relevant financial relationships | Carlos Mena-Hurtado: DO have relevant financial relationships ; Consultant:Cook:Active (exists now) ; Research Funding (PI or named investigator):Merck :Active (exists now) ; Research Funding (PI or named investigator):Abbott:Active (exists now) ; Research Funding (PI or named investigator):Shockwave:Active (exists now) ; Consultant:BD:Active (exists now) | Matthew Menard: DO have relevant financial relationships ; Advisor:Janssen:Active (exists now) | Alik FARBER: DO have relevant financial relationships ; Consultant:Sanifit:Active (exists now) ; Advisor:DialysisX:Active (exists now) ; Advisor:iThera:Active (exists now) ; Consultant:BiogenCell:Active (exists now) ; Consultant:LeMaitre:Active (exists now) | Kenneth Rosenfield: No Answer | Michael Strong: DO NOT have relevant financial relationships | Gheorghe Doros: No Answer | Philip Goodney: DO NOT have relevant financial relationships | Gaelle Romain: DO NOT have relevant financial relationships | Jacob Cleman: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Risk Factors Re-Defined: Fresh Approaches to Assessment and Management

Saturday, 11/16/2024 , 12:50PM - 02:15PM

Moderated Digital Poster Session

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