Impella in Myocardial Infarction Complicated by Cardiogenic Shock: A Meta-Analysis
Abstract Body (Do not enter title and authors here): Background: Despite recent technological advancements, myocardial infarction complicated with cardiogenic shock is associated with high mortality. Impella has been advocated as an adjunct to the standard of care, but conflicting data has hindered greater utilization. We performed an updated meta-analysis with the recent data. Methods: We searched PubMed and Embase, screened 787 articles, and identified twelve studies that met eligibility criteria; these randomized controlled trials and cohort studies compared Impella to other mechanical circulatory support systems in patients with myocardial infarction complicated by cardiogenic shock. We evaluated groups with twenty-three metrics related to adverse events and clinical outcomes. A random effects model assessed heterogeneity between studies. Results: We did not find a statistically significant difference between groups across all twenty-three included metrics: in-house mortality, 30-day mortality, 6-month mortality, brain death, cardiovascular death, non-cardiac mortality, myocardial infarction, need for repeat percutaneous coronary intervention, need for left ventricular assist device, coronary bypass artery graft, stroke, limb ischemia, hemolysis, major bleeding, thrombosis, and sepsis. Table 1 Our subgroup analyses for intra-aortic balloon pump, extracorporeal membrane oxygenation, and medical management revealed similar results for mortality. In terms of bleeding, IABP was associated with better outcomes whereas ECMO was associated with worse outcomes than Impella. Impella was also associated with an increased risk of thrombosis as compared to IABP. Table 2,3,4 Conclusions: Our updated meta-analysis did not relate Impella use to better outcomes. Heterogeneity in the timing of device implantation calls for stricter reporting in subsequent larger, randomized controlled trials.
Haider, Mobeen
( Carle Foundation Hospital
, Champaign
, Illinois
, United States
)
Ahmed, Munis
( Springfield Regional Medical Center
, Springfield
, Ohio
, United States
)
Karamat, Mubashar Karamat
( Ascension St Francis Medical Center
, Evanston
, Illinois
, United States
)
Sattar, Yasar
( West Virginia University
, Morgantown
, West Virginia
, United States
)
Alraies, M Chadi
( Detroit Medical Center
, Detroit
, Michigan
, United States
)
Berry, Ryan
( Authority Healt
, Detroit
, Michigan
, United States
)
Hamza, Mohammad
( Albany Medical Center
, Aldan
, Pennsylvania
, United States
)
Upreti, Prakash
( Sands-Constellation Heart Institute, Rochester Regional Health
, Rochester
, New York
, United States
)
Mir, Junaid
( University of missouri
, Columbia
, Missouri
, United States
)
Naveed, Hamza
( HCA
, Houston
, Texas
, United States
)
Naseer, Usman
( USD Sanford School of Medicine
, Sioux Falls
, South Dakota
, United States
)
Pandya, Krutarth
( Cleveland Clinic
, Cleveland
, Ohio
, United States
)
Harmouch, Khaled M.
( Detroit Medical Center
, Detroit
, Michigan
, United States
)
Author Disclosures:
Mobeen Haider:DO NOT have relevant financial relationships
| Munis Ahmed:DO NOT have relevant financial relationships
| Mubashar Karamat Karamat:No Answer
| Yasar Sattar:No Answer
| M Chadi Alraies:DO NOT have relevant financial relationships
| Ryan Berry:No Answer
| Mohammad Hamza:DO NOT have relevant financial relationships
| Prakash Upreti:DO NOT have relevant financial relationships
| junaid Mir:DO NOT have relevant financial relationships
| Hamza Naveed:No Answer
| Usman Naseer:DO NOT have relevant financial relationships
| Krutarth Pandya:DO NOT have relevant financial relationships
| Khaled M. Harmouch:No Answer
