Scientific Sessions 2024  /  Post Acute Management in the ACS Population  /  Impact of sodium-glucose co-transporter inhibitors on cardiovascular outcomes in patients with acute myocardial infarction: Systematic Review and Meta-Analysis
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American Heart Association

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Final ID: MDP732

Impact of sodium-glucose co-transporter inhibitors on cardiovascular outcomes in patients with acute myocardial infarction: Systematic Review and Meta-Analysis

Abstract Body (Do not enter title and authors here):
Background:
The role of sodium-glucose co-transporter inhibitors (SGLT-2i) in heart failure is well-established. However, evidence supporting their use in acute myocardial infarction remains limited.
Methods:
Two independent researchers conducted a comprehensive literature review on PubMed and Embase up to April 2024. They identified 19 articles, consisting of randomized controlled trials and observational studies, investigating the use of SGLT-2i in acute myocardial infarction. The analysis focused on cardiovascular outcomes, including all-cause mortality, cardiovascular mortality, major adverse cardiovascular events (MACE), heart failure exacerbation, strokes, and recurrence of acute coronary syndrome.
Results:
Our pooled analysis of 20,190 participants revealed a significant reduction in major adverse cardiovascular events (MACE) [OR 0.54 (0.39-0.76), P < 0.0003] and hospitalization due to heart failure [OR 0.5850 (0.43-0.79), P < 0.0004] in the SGLT-2i group compared to the control group. In contrast, there were no clinically significant differences between the SGLT-2i and control groups regarding all-cause mortality, cardiovascular mortality, recurrence of acute coronary syndrome, or new-onset arrhythmia.
Conclusion:
Our study highlights that among patients with acute myocardial infarction, the use of SGLT-2i reduces MACE and hospitalizations due to heart failure. However, there was no significant reduction in mortality, recurrence of acute coronary syndrome, or arrhythmia in the SGLT-2i group.
  • Akkawi, Mohammad  ( Detroit Medical Center , Detroit , Michigan , United States )
  • Damlakhy, Ahmad  ( Detroit Medical Center , Detroit , Michigan , United States )
  • Upreti, Prakash  ( Sands-Constellation Heart Institute, Rochester Regional Health , Rochester , New York , United States )
  • Hamza, Mohammad  ( Albany Medical Center , Aldan , Pennsylvania , United States )
  • Rajak, Kripa  ( UPMC , Harrisburg , Pennsylvania , United States )
  • Turkmani, Mustafa  ( McLaren Healthcare , Detriot , Michigan , United States )
  • Harmouch, Khaled M.  ( Detroit Medical Center , Detroit , Michigan , United States )
  • Bahar, Yasemin  ( Wayne State University , Detroit , Michigan , United States )
  • Alraies, M Chadi  ( Detroit Medical Center , Detroit , Michigan , United States )
    • Author Disclosures:
    Mohammad Akkawi: DO NOT have relevant financial relationships | ahmad damlakhy: No Answer | Prakash Upreti: DO NOT have relevant financial relationships | Mohammad Hamza: DO NOT have relevant financial relationships | Kripa Rajak: DO NOT have relevant financial relationships | Mustafa Turkmani: DO NOT have relevant financial relationships | Khaled M. Harmouch: No Answer | Yasemin Bahar: DO NOT have relevant financial relationships | M Chadi Alraies: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Post Acute Management in the ACS Population

Saturday, 11/16/2024 , 02:50PM - 04:05PM

Moderated Digital Poster Session

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