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American Heart Association

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Final ID: MDP1401

Efficacy of Atrial Shunt Devices in Heart Failure with Preserved Ejection Fraction: A Systematic review and Meta-analysis of randomized trials.

Abstract Body (Do not enter title and authors here): Background: The potential benefit of an iatrogenic interatrial shunt in heart failure (HF) is based on observations wherein decompression of the pressure-overloaded left atrium appears beneficial. Consequently, devices designed to mimic this effect have been developed. However, their effectiveness remains controversial.
Methods: We searched PubMed, Cochrane, and Embase for randomized controlled trials (RCTs) comparing the use of atrial shunt devices (ASD) versus standard therapy in patients with heart failure with preserved ejection fraction (HFpEF). The outcomes of interest were: (1) quality of life assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and (2) HF events after ASD intervention. Heterogeneity was examined with I2 statistics. Statistical analysis was performed using R Studio 4.3.2.
Results: A total of 3 RCTs were included, encompassing 966 patients, of whom 479 (49.5%) were in the ASD group. Most of the participants were female (53%), had a three or higher NYHA class(92%), with a mean age of 72.5 years and a mean follow-up of 1.2 years. In the pooled analysis, there was no difference between groups in improvement of KCCQ (MD 0.65; 95% CI −2.22,3.52; p=0.66;I2=0%; Fig 1) and HF events (RR 1.06; 95% CI 0.81,1.39; p=0.68;I2=0%; Fig 2).
Conclusion: In this meta-analysis of patients with HFpEF, ASD therapy was not associated with improvements in quality of life and HF events.
  • Prata, Alonzo  ( UFES , Vitoria , Brazil )
  • Gioli-pereira, Luciana  ( Albert Einstein Hospital - SBIBAE , São Paulo , Brazil )
  • Katsuyama, Eric  ( Faculdade de Medicina do ABC , Sao Paulo , Brazil )
  • Scardini, Pedro Gabriel  ( EMESCAM , Vitoria , Brazil )
  • Coan, Ana Carolina  ( Federal University of Espirito Santo , Vitoria , Brazil )
  • Fukunaga, Christian  ( Faculdade de Medicina do ABC , Sao Paulo , Brazil )
  • Fernandes, Julia  ( Albert Einstein Hospital - SBIBAE , São Paulo , Brazil )
  • Falco Neto, Wilson  ( Faculdade de Medicina de Catanduva , Catanduva , Brazil )
  • Petri Santos Pinheiro, Rafael  ( UFRJ , Rio de janeiro , Brazil )
  • Andrade, Naieli  ( Escola Bahiana de Medicina e Saúde Pública , Salvador , Brazil )
  • Author Disclosures:
    Alonzo Prata: DO NOT have relevant financial relationships | Luciana Gioli-Pereira: DO NOT have relevant financial relationships | Eric Katsuyama: DO NOT have relevant financial relationships | Pedro Gabriel Scardini: DO NOT have relevant financial relationships | Ana Carolina Coan: DO NOT have relevant financial relationships | Christian Fukunaga: DO NOT have relevant financial relationships | Julia Fernandes: DO NOT have relevant financial relationships | Wilson Falco Neto: DO NOT have relevant financial relationships | Rafael Petri Santos Pinheiro: DO NOT have relevant financial relationships | Naieli Andrade: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

What Can Big Data Teach Us About Heart Failure

Monday, 11/18/2024 , 12:50PM - 02:15PM

Moderated Digital Poster Session

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