Safety and efficacy of the bioactive titanium-nitric-oxide coated stent in contrast to everolimus-eluting stents (EES) among patients diagnosed with ACS: An updated meta-analysis.
Abstract Body (Do not enter title and authors here): Introduction: Drug-eluting stents (DES) have effectively decreased the incidence of restenosis; however, recent investigations raised the potential for late stent thrombosis (LST). Bioactive stent (BAS) coated with titanium-nitride-oxide has demonstrated favourable outcomes with conflicting results in individuals with acute coronary syndromes. We aimed to outline the comparison of BAS and EES among patients diagnosed with acute coronary syndrome (ACS). Methods: We systematically searched PubMed, Web of Science, Scopus, and Cochrane Central, and EMBASE from inception until February 2024. We included randomised controlled trials (RCTs) and observational studies comparing bioactive titanium-nitric-oxide coated stent stents versus EES stents. The primary outcome was MACE, while secondary outcomes were MI, Cardiac death, All-Cause Death, definite stent thrombosis, and Minimal lumen diameter. All data were pooled as either Mean difference in the random effect model with the corresponding SD or pooled as RR and 95% CI for dichotomous data. Results: Seven RCTs involving 3101 patients were included in the analysis. BAS coated was associated with a reduction in definite stent thrombosis (OR= 0.35, 95% CI [ 0.16 to 0.77], P=0.009), MI (OR= 0.47, 95% CI [ 0.34 to 0.64], P=<0.001), and minimal lumen diameter (MD= -0.22, 95% CI [ -0.35 to -0.10], P=0.0004). However, there was no significant difference in terms of MACE, all-cause mortality, or cardiac mortality between the two studied approaches. Conclusion: BAS showed a reduction in definite stent thrombosis, MI, and minimal lumen diameter, with no significant difference in other reported outcomes. This opens the door for large-volume RCTs to validate the current findings.
Abdelaziz, Ahmed
( Faculty of Medicine Al-Azhar University
, Menoufia
, Egypt
)
Banour, Sandi
( ruby hospital
, West Verginia
, Virginia
, United States
)
Abdelazeem, Basel
( West Virginia University
, Morgantown
, West Virginia
, United States
)
Desouki, Mariam
( Faculty of Medicine Alexandria University
, Alexandria
, Egypt
)
Ramadan, Shrouk
( Ain Shams University
, Cairo
, Egypt
)
Elaraby, Ahmed
( Faculty of Medicine Al-Azhar University
, Menoufia
, Egypt
)
Mohamed, Ahmed
( Faculty of medicine, Tanta university
, El mahallah e kobra
, Egypt
)
Afify, Raneem
( Facylty of medicine, Tanta universi
, El mahallah el kobra
, Egypt
)
Nasr, Ahmed
( Damietta faculty of medicine, Al-Azher university
, Clifton
, New Jersey
, United States
)
Ali, Ahmed Hamdy G.
( Faculty of Medicine, Ogarev Mordovia State University, Saransk, Russia.
, Saransk
, Russian Federation
)
Arian, Roua
( Faculty of Medicine, University of Aleppo, Aleppo, Syria
, Aleppo
, Syrian Arab Republic
)
Author Disclosures:
Ahmed Abdelaziz:DO NOT have relevant financial relationships
| Sandi Banour:DO NOT have relevant financial relationships
| Basel Abdelazeem:DO NOT have relevant financial relationships
| Mariam Desouki:DO NOT have relevant financial relationships
| Shrouk Ramadan:DO NOT have relevant financial relationships
| Ahmed Elaraby:No Answer
| Ahmed Mohamed:DO NOT have relevant financial relationships
| Raneem Afify:DO NOT have relevant financial relationships
| Ahmed Nasr:DO NOT have relevant financial relationships
| Ahmed Hamdy G. Ali:DO NOT have relevant financial relationships
| Roua Arian:DO NOT have relevant financial relationships
