Abstract Body (Do not enter title and authors here): Background: The latest guidelines advocate for catheter ablation (CA) over standard medical therapy (SMT) for managing atrial fibrillation (AF) in patients with heart failure with reduced ejection fraction (HFrEF). However, significant knowledge gaps exist regarding the effectiveness of CA vs. SMT in patients with heart failure with preserved ejection fraction (HFpEF).
Methods: PubMed, Scopus, and Embase until February 2024 were systematically searched. Given the limited number of randomized studies, propensity score-matched observational studies comparing CA with SMT in AF patients with HFpEF were also included. The primary outcome was a composite endpoint of all-cause mortality and HF hospitalization.
Results: Eight studies that enrolled 17,717 SMT and 2537 CA patients were included. CA was associated with a significantly lower risk of the composite endpoint of all-cause mortality and HF hospitalization (HR 0.69, 95% CI: 0.40-0.98). The risk of HF hospitalization (HR 0.48, 95% CI: 0.17-0.80), cardiovascular mortality (HR 0.27, 95% CI: -0.06-0.61), and AF recurrence (HR 0.53, 95% CI: 0.37-0.70) were also lower in the CA group.
Conclusion: CA demonstrated significant cardiovascular morbidity and mortality benefits when compared to SMT in the HFpEF population.