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American Heart Association

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Final ID: Mo4070

Short Term Outcomes Of Transcatheter Tricuspid Valve Interventions On Post-Procedural Length Of Hospital Stay, Readmissions For Heart Failure And Procedure Success If An Intracardiac Device Is Present: A Systematic Review And Meta-Analysis In A New Era Of Tricuspid Interventions

Abstract Body (Do not enter title and authors here): Background: Tricuspid regurgitation (TR) is no longer considered forgotten. Transcatheter tricuspid valve repair/replacement (TVRR) has become widely accepted as gauged by clinical outcomes. FDA approved two tricuspid valve devices for the purpose of improving quality of life and not necessarily to improve TR severity. We aim to support evidence-based use of TVRR, by summarizing the latest evidence on the clinical effectiveness in terms of post-procedural length of hospital stay, readmissions for heart failure and procedure success if an Intracardiac device is present.

Methods: We searched Pubmed, Embase and Cochrane databases and performed a meta-analysis of the included cohort studies using a fixed-effects model. Studies were excluded if they did not present an outcome in each intervention group or did not have enough information required for continuous data comparison. We performed a meta-analysis of hazard ratio (HR) for two outcomes and odds ratio (OR) for one outcome using the random effects model to remove inconsistency and compared the results with fixed effects model. The compared findings of both methods were similar. The variables used for analysis were number of events in exposure group and total amount of events. All data analyses were performed using MedCalc® Statistical Software version 22.023.

Results: Of 161 potentially relevant studies, 8 retrospective studies with a total of 1,717 patients were included in the meta-analysis. Procedure (TVRR) success was associated with fewer readmissions for heart failure in all three studies included in the analysis of pooled HR (HR = 0.46, 95% confidence interval [CI]: 0.33 - 0.63, p<0.001). Procedure success was also associated with shorter length of hospitalization post-procedure in all three studies included in the analysis of pooled HR (HR = 0.48, 95% CI: 0.33 - 0.72, p<0.001). There was no significant association between procedure success and having an intra-cardiac device in all three studies included in the analysis of pooled OR (OR = 0.79, 95% CI: 0.56 - 1.12, p=0.18).

Conclusion: Our meta-analysis showed that successful TVRR for high risk patients with severe TR is associated with significant positive outcomes on post-procedural length of hospital stay and readmissions for heart failure, regardless of presence of an intracardiac device. With emerging improvements in device technology and procedural performance, TVRR should be considered in severe and functional TR, to improve clinical prognosis.
  • Kumanayaka, Dilesha  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Hernandez Perez, Laura  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Aiman, Wajeeha  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Abu Ruman, Yazeed  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Chandra, Aishwarya  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Patel, Palak  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Patel, Aharnish  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Suleiman, Addi  ( NYMC, Saint Michaels Medical Center , Newark , New Jersey , United States )
  • Author Disclosures:
    Dilesha Kumanayaka: DO NOT have relevant financial relationships | Laura Hernandez Perez: DO NOT have relevant financial relationships | Wajeeha Aiman: No Answer | Yazeed Abu ruman: DO NOT have relevant financial relationships | Aishwarya Chandra: No Answer | Palak Patel: DO NOT have relevant financial relationships | Aharnish Patel: DO NOT have relevant financial relationships | Addi Suleiman: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Making it Right: Interventions for the Tricuspid Valve and Right Heart

Monday, 11/18/2024 , 10:30AM - 11:30AM

Abstract Poster Session

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