Cardiovascular Risk Factors and Associations of Chronic Inflammatory-Related Disease in the Multi-Ethnic Study of Atherosclerosis
Abstract Body (Do not enter title and authors here): Background Inflammation plays a role in the development of cardiovascular disease (CVD). We have defined various non-cardiovascular and non-cancer conditions, both infectious and non-infectious, with a common basis of inflammation; collectively termed Chronic Inflammatory-Related Disease (ChrIRD). We have previously described that ChrIRD is common, associated with baseline inflammatory marker levels, associated with high mortality, and has a bidirectional association with CVD. The clinical implications of these data require further study. Aims We hypothesize that many traditional risk factors for CVD are also associated with ChrIRD and that ChrIRD has additional unique risk factors. We also hypothesize that the treatment of traditional CVD risk factors is associated with a decreased likelihood of ChrIRD. Methods We studied MESA participants free of overt CVD or significant illness at baseline. ChrIRD was determined based on review of ICD codes for hospitalizations and deaths. Incident CVD was adjudicated by review of medical records. We performed proportional hazards regression (time-dependent for CVD) to identify factors associated with a first diagnosis of ChrIRD. All variables were simultaneously entered into the model. Results Participants (n=6155) had mean age 62±10 years and 47% male gender. ChrIRD was observed in 24% and CVD in 18%; including 8% with both conditions. Participants with a diagnosis of CVD, older age, higher heart rate, higher BMI, current or ever smoking status, higher HDL, higher baseline IL6 and GlycA levels, and NSAID use had increased likelihood of ChrIRD. Whereas those with female sex, higher total cholesterol, and statin use had a decreased likelihood of ChrIRD. Participant race/ethnicity, blood pressure, diabetes status, antihypertensive use, aspirin use, baseline CRP level, and baseline D-dimer level were not associated with ChrIRD. Regression results are summarized in Table 1. Conclusions ChrIRD shares some risk factors with CVD, while other risk factors are opposite. Better understanding of ChrIRD could eventually lead to improved patient care.
Manning, Evan
( University of Minnesota
, Saint Paul
, Minnesota
, United States
)
Shroff, Gautam
( Hennepin Healthcare
, Minneapolis
, Minnesota
, United States
)
Jacobs, David
( University of Minnesota
, Minnetonka
, Minnesota
, United States
)
Duprez, Daniel
( University of Minnesota
, Minneapolis
, Minnesota
, United States
)
Author Disclosures:
Evan Manning:DO NOT have relevant financial relationships
| Gautam Shroff:DO NOT have relevant financial relationships
| David Jacobs:DO NOT have relevant financial relationships
| Daniel Duprez:DO have relevant financial relationships
;
Research Funding (PI or named investigator):Regeneron:Past (completed)
; Research Funding (PI or named investigator):Novo Nordisk:Past (completed)
; Research Funding (PI or named investigator):Amgen:Active (exists now)
; Research Funding (PI or named investigator):Novartis:Active (exists now)
; Research Funding (PI or named investigator):Arrowhead:Active (exists now)
