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American Heart Association

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Final ID: OGCTP30

CIRCA Chronotype and Stroke Registry Study

Abstract Body: Background: Accumulating evidence suggests that circadian biology modulates the cerebral response to ischemia. Each individual’s endogenous circadian system influences their tendency to express an earlier or later behavioral sleep/wake schedule, i.e., to be more of a morning type of evening type, respectively. Since chronotype is reflective of the influence of the underlying circadian system, determining its relationship with stroke occurrence and severity may help in predicting interindividual differences in stroke susceptibility and evolution.
Objective: Characterize the association of chronotype with presentation, course, and outcome of acute ischemic stroke in adults and children 6 years old and older.
Design: International, observational, prospective, multicenter study at 10 centers in the United States, Europe, and Asia. Most data will be abstracted from routine clinical documentation in patient medical records. Patients and/or families/caregivers will be asked to answer two questions about the sleep episode prior to stroke onset, one question about any recent travel involving time zone change, and the six questions from the Ultra-Short Munich ChronoType Questionnaire, which includes recent shift-work history.
Population: Up to 1000 adult patients and 100 pediatric patients (6-17 years old) will be included. Consecutive patients with acute ongoing cerebral ischemia who present within 24 hours of last known well are eligible. Ongoing acute cerebral ischemia is defined as presence of neurologic deficits due to cerebral ischemia at the time of hospital presentation. Patients with resolution of symptoms prior to hospital arrival and final diagnosis of TIA; onset of acute cerebral ischemia during hospital admission; or discharge diagnosis of a stroke mimicking condition are excluded.
Intervention: None
Outcome Measures: Discharge modified Rankin Scale (mRS) score. Presenting National Institutes of Health Stroke Scale (NIHSS) score and Alberta Stroke Program Early Computed Tomography Score (ASPECTS). Ischemic stroke etiologic subtype, response to thrombolysis, and response to thrombectomy.
Analysis: Chronotype will be calculated using the Ultra-Short Munich ChronoType Questionnaire and is a continuous variable of a time between 0 and 24. Questionnaire responses also will be used to calculate social jet lag (SJL). As this is a registry study, all analyses will be considered exploratory.
  • Veloudiou, Orsalia  ( Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich , Munich , Germany )
  • Mergenthaler, Philipp  ( Charité–Universitätsmedizin , Berlin , Germany )
  • Ning, Mingming  ( MASS GENERAL HOSP HARVARD MED , Boston , Massachusetts , United States )
  • Klerman, Elizabeth  ( MASS GENERAL HOSP HARVARD MED , Boston , Massachusetts , United States )
  • Scheer, Frank  ( Brigham and Women's Hospital , Boston , Massachusetts , United States )
  • Lo, Eng  ( MASS GENERAL HOSP HARVARD MED , Boston , Massachusetts , United States )
  • Mun, Katherine  ( David Geffen School of Medicine, University of California Los Angeles , Los Angeles , California , United States )
  • Saver, Jeffrey  ( David Geffen School of Medicine, University of California Los Angeles , Los Angeles , California , United States )
  • Tiedt, Steffen  ( Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich , Munich , Germany )
  • Calleja, Patricia  ( UNIVERSIDAD COMPLUTENSE , Madird , Spain )
  • Lizasoain, Ignacio  ( UNIVERSIDAD COMPLUTENSE , Madird , Spain )
  • Lee, Sarah  ( Stanford University , Stanford , California , United States )
  • Albers, Greg  ( Stanford University , Stanford , California , United States )
  • Balami, Joyce  ( UNIVERSITY OF OXFORD , Oxford , United Kingdom )
  • Buchan, Alastair  ( UNIVERSITY OF OXFORD , Oxford , United Kingdom )
  • Pelz, David  ( LONDON HEALTH SCIENCES CENTRE , LONDON , Ontario , Canada )
  • Author Disclosures:
    Orsalia Veloudiou: No Answer | Philipp Mergenthaler: DO NOT have relevant financial relationships | MingMing Ning: DO NOT have relevant financial relationships | Elizabeth Klerman: DO NOT have relevant financial relationships | Frank Scheer: DO NOT have relevant financial relationships | Eng Lo: DO NOT have relevant financial relationships | Katherine Mun: DO NOT have relevant financial relationships | Jeffrey Saver: DO have relevant financial relationships ; Consultant:Abbott:Active (exists now) ; Individual Stocks/Stock Options:Viz.ai:Active (exists now) ; Individual Stocks/Stock Options:Let's Get Proof:Active (exists now) ; Individual Stocks/Stock Options:Neuronics:Active (exists now) ; Consultant:Genentech:Expected (by end of conference) ; Consultant:Roche:Active (exists now) ; Consultant:Novo Nordisc:Active (exists now) ; Consultant:AstraZeneca:Active (exists now) ; Consultant:BrainQ:Active (exists now) ; Consultant:Medtronic:Active (exists now) | Steffen Tiedt: DO NOT have relevant financial relationships | Patricia Calleja: DO NOT have relevant financial relationships | Ignacio Lizasoain: DO NOT have relevant financial relationships | Sarah Lee: DO NOT have relevant financial relationships | Greg Albers: DO have relevant financial relationships ; Consultant:iSchemaView:Active (exists now) ; Consultant:Genentech:Past (completed) ; Ownership Interest:iSchemaView:Active (exists now) | Joyce Balami: DO NOT have relevant financial relationships | Alastair Buchan: DO NOT have relevant financial relationships | DAVID PELZ: No Answer
Meeting Info:
Session Info:

Ongoing Clinical Trials Posters

Thursday, 02/06/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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