Abstract Body: Background
Coffee is one of the most widely consumed beverages in the world, and contains caffeine in it. Previous pre clinical studies and meta analysis have shown conflicting results with majority supporting that coffee consumption was associated with lower risk of stroke.
Objective
This study aims to investigate the association between coffee consumption and risk of stroke.
Methods
We performed a systematic literature search on PubMed, EMBASE, and ClinicalTrials.gov for relevant studies from inspection until August 10th, 2024, without any language restrictions. Risk ratios (RR) and 95% confidence intervals (CI) were pooled using a random-effect model, and a p-value of <0.05 was considered statistically significant.
Results
A total of 10 studies with 2,35,969 patients were included. The mean age of the patients was 55.6 years. Pooled analysis showed that people who consumed >4 cup of coffee/day were having higher odds of all stroke (RR, 1.33(95%CI: 1.05-1.67). However, there was no such association between low to moderate (1-3 cup) coffee consumption and stroke risk (RR, 1.24(95%CI: 0.94-1.64).
Conclusion
High coffee consumption was associated with higher risk of stroke, however not with low to moderate coffee consumption. It can help individuals who are addicted to more coffee drinking/day to avoid stroke risk.