Abstract Body: Introduction: The majority of patients with cerebral venous thrombosis (CVT) achieve functional independence (modified Rankin Score [mRS] 0-2), although many continue to experience residual symptoms that negatively impact quality of life. Patient-reported outcome measures (PROMs) provides a means to assess these symptoms, capturing aspects of health often missed by clinician-reported assessments. We evaluated differences in PROMs across several health domains between patients with CVT and ischemic stroke.

Methods: This observational cohort study included patients hospitalized for ischemic stroke or CVT who had a follow-up visit in a cerebrovascular clinic January 1, 2019 to April 30, 2024 and completed at least one PROM within three months of their last cerebrovascular event. Routinely collected PROMs included Patient Health Questionnaire-9, PROMIS Global Health, NeuroQoL computer adaptive testing (CAT) cognitive function, and the following PROMIS CAT scales: pain interference, physical function, satisfaction with social roles, fatigue, self-efficacy and sleep disturbance. Propensity score matching was used to pair CVT patients with ischemic stroke patients in 1:3 ratio based on demographic characteristics, mRS, Charlson comorbidity index, and time since last cerebrovascular event.

Results: Out of 72 CVT and 2,533 ischemic stroke patients who met study criteria, 69 CVT and 196 ischemic stroke patients were matched and analyzed (average age 47.5±17.0 yrs, 62.6% female, 74.7% white race). Evidence of brain tissue injury on MRI was present in 22 (30.6%) of CVT patients. The median mRS of both CVT and ischemic stroke patients was 1 [IQR 0,1]. Except for sleep disturbance, PROMIS scores for both groups were meaningfully worse than the general population mean of 50. Worst scores were seen with physical function followed by fatigue and satisfaction with social roles. Pain interference scores were significantly worse in patients with CVT than those with ischemic stroke (58.0±10.5 vs 53.8±10.4; p=0.008); domain scores were otherwise similar between groups (Table).

Conclusion: Despite low rate of brain injury on MRI, CVT patients had worse pain interference and similar severity and pattern of other PROM scores compared to a matched sample of ischemic stroke patients. This suggests that a holistic care approach addressing pain and the broader spectrum of outcomes, in addition to the primary vascular pathology, could be beneficial in the management of patients with CVT.