Abstract Body: Introduction: The long-term effects of ischemic stroke on cognition and mental health remain poorly understood, leading to mismatches in perceptions of overall disability despite otherwise qualifying as having ‘good’ or ‘excellent’ outcomes on traditional measures like the modified Rankin Scale (mRS). In our multicenter analysis, we aim to explore the prevalence and factors associated with patient-reported outcomes in patients who underwent reperfusion therapy and otherwise achieved good outcomes as defined by an mRS of 0-2.
Methods: Retrospective registries of acute ischemic stroke patients at Cooper University Hospital (2021-2024) and Hospital Vall d’Hebron in Barcelona, Spain (2020-2021) were queried for patients who were treated with reperfusion therapy and achieved 90-day mRS 0-2. These patients were surveyed with the PROMIS Global-10 scale. The PROMIS Global-10 measures two domains: physical health (PROMIS-PH) and mental health (PROMIS-MH). The primary outcome was the rate of fair or poor PROMIS-MH scores (≤11), which was summarized as a frequency. Univariable and multivariable linear regressions for PROMIS-MH scores were performed to identify independently-associated factors.
Results: Of 162 patients, 42% reported fair or poor (PROMIS-MH≤11) mental health outcome scores. Clinical factors independently associated with PROMIS-MH scores in a multivariable linear regression include: sex, tobacco use, PROMIS-PH score, and National Institutes of Health Stroke Scale at 3-day follow-up.
Conclusions: Despite having mRS 0-2, patients do not necessarily have good long-term mental health outcomes. To better serve our stroke patients, emphasis should extend beyond traditional, limited measures and encompass additional dimensions of evaluation, including patient-reported mental health outcomes.