International Stroke Conference 2025  /  Risk Factors and Prevention Posters I  /  Cancer and Left Atrial Enlargement in Patients with Ischemic Stroke
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American Heart Association

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Final ID: WP272

Cancer and Left Atrial Enlargement in Patients with Ischemic Stroke

Abstract Body: Background: Cancer is associated with an increased risk for atrial fibrillation. However, there are no existing data supporting an independent relationship between cancer and atrial cardiopathy, another atrial pathology associated with increased acute ischemic stroke (AIS) risk. We investigated the relationship between atrial cardiopathy and cancer among patients with AIS.

Methods: We conducted a retrospective cross-sectional study among consecutive patients hospitalized with AIS at a quaternary care center in New York City from 2011 through 2016. The study exposure was active cancer. The study outcome was atrial cardiopathy, defined as a left atrial volume index ≥35 mL/m2 as determined by echocardiography. We used multivariable logistic regression, adjusting for relevant confounders, to evaluate the relationship between active cancer and atrial cardiopathy. We performed a subgroup analysis among patients with embolic stroke of undetermined source (ESUS).

Results: The final cohort included 1104 patients with AIS, of whom 10% had active cancer and 47% had atrial cardiopathy. Patients with atrial cardiopathy, compared to those without, were older (median age, 77 years versus 68 years), and more frequently had hypertension, coronary disease, and atrial fibrillation. Active cancer was present in 9.6% of patients with atrial cardiopathy (n=50/520) and 10.4% of patients without (n=61/584). In multivariable models, there was no association between active cancer and atrial cardiopathy among the overall AIS cohort (adjusted odds ratio, 0.91; 95% confidence interval, 0.60-1.37) nor in patients with ESUS (adjusted odds ratio, 0.64; 95% confidence interval, 0.30-1.36).

Conclusion: When defining atrial cardiopathy according to left atrial volume, we did not find an association between cancer and atrial cardiopathy in patients with AIS, including among patients with ESUS. Future studies, evaluating other atrial cardiopathy biomarkers and settings, are needed to further investigate any potential link between cancer and atrial cardiopathy.
  • Pawar, Anokhi  ( Weill Cornell Medicine , New York , New York , United States )
  • Kamel, Hooman  ( Weill Cornell Medicine , New York , New York , United States )
  • Navi, Babak  ( Weill Cornell Medicine , New York , New York , United States )
  • Beyeler, Morin  ( Bern University Hospital and University of Bern , Bern , Switzerland )
  • Buffle, Eric  ( Bern University Hospital and University of Bern , Bern , Switzerland )
  • Zhang, Cenai  ( Weill Cornell Medicine , New York , New York , United States )
  • Liao, Vanessa  ( Weill Cornell Medicine , New York , New York , United States )
  • Liberman, Ava  ( Weill Cornell Medicine , New York , New York , United States )
  • Pabst, Thomas  ( Bern University Hospital and University of Bern , Bern , Switzerland )
  • Berger, Martin D.  ( Bern University Hospital and University of Bern , Bern , Switzerland )
  • Jung, Simon  ( Bern University Hospital and University of Bern , Bern , Switzerland )
    • Author Disclosures:
    Anokhi Pawar: DO NOT have relevant financial relationships | Hooman Kamel: DO have relevant financial relationships ; Other (please indicate in the box next to the company name):Financial disclosures for Hooman Kamel: a PI role in the ARCADIA trial, which received in-kind study drug from the BMS-Pfizer Alliance for Eliquis and ancillary study support from Roche Diagnostics; a Deputy Editor role for JAMA Neurology; clinical trial steering/executive committee roles for the STROKE-AF (Medtronic), LIBREXIA-AF (Janssen), and LAAOS-4 (Boston Scientific) trials; consulting or endpoint adjudication committee roles for AbbVie, AstraZeneca, Boehringer Ingelheim, and Novo Nordisk; and household ownership interests in TETMedical, Spectrum Plastics Group, and Ascential Technologies.:Active (exists now) | Babak Navi: DO have relevant financial relationships ; Independent Contractor:MindRhythm, Inc.:Past (completed) | Morin Beyeler: DO NOT have relevant financial relationships | Eric Buffle: No Answer | Cenai Zhang: DO NOT have relevant financial relationships | Vanessa Liao: DO NOT have relevant financial relationships | Ava Liberman: DO NOT have relevant financial relationships | Thomas Pabst: No Answer | Martin D. Berger: DO NOT have relevant financial relationships | Simon Jung: No Answer
Meeting Info:

International Stroke Conference 2025

2025

Los Angeles, CA

Session Info:

Risk Factors and Prevention Posters I

Wednesday, 02/05/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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