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American Heart Association

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Final ID: WP312

Left Atrial Septal Pouch and Risk of Cryptogenic Stroke: A Systematic Review and Meta-Analysis

Abstract Body: Background: The left atrial septal pouch (LASP) is a blind-ended structure resulting from incomplete fusion of the septum primum and septum secundum during embryonic development, unlike a patent foramen ovale that leaves an interatrial channel open. Recent studies have suggested that LASP could serve as a site for thrombus formation, although its role as an independent risk factor for thromboembolic stroke remains unclear. The aim of this systematic review and meta-analysis was to evaluate and summarize the evidence that the presence of a LASP is a risk factor for cryptogenic stroke.

Methods: We searched PubMed and EMBASE to identify relevant studies. The association between LASP and cryptogenic stroke was estimated by the odds ratio (OR) and 95% confidence interval (CI). Heterogeneity was assessed by χ2-based Q-test.

Results: Eight studies with 2,357 participants from the USA, Europe, and Asia were used in the meta-analysis. We found a significant association between cryptogenic stroke and the presence of LASP (OR 1.60, 95% CI 1.27 to 2.02, p < 0.001). No evidence of heterogeneity was found (Q=6.33, p = 0.50).

Conclusions: This systematic review and meta-analysis adds supports a relationship between LASP and cryptogenic stroke. Further studies are needed to characterize how LASP may impact the risk of recurrent stroke, as well as identification of optimal stroke prevention strategies in the presence of LASP.
  • Xu, Jennifer  ( University of California, Irvine , Orange , California , United States )
  • Kang, Jihoon  ( Seoul National University Bundang Hospital , Seongnam , Korea (the Republic of) )
  • Schilling, Jonathan  ( Cardiovascular Institute of Los Robles Health System , Thousand Oaks , California , United States )
  • Paganini-hill, Annlia  ( University of California, Irvine , Orange , California , United States )
  • Kim, Jin Kyung  ( University of California, Irvine , Orange , California , United States )
  • Fisher, Mark  ( University of California, Irvine , Orange , California , United States )
  • Author Disclosures:
    Jennifer Xu: DO NOT have relevant financial relationships | Jihoon Kang: DO NOT have relevant financial relationships | Jonathan Schilling: No Answer | Annlia Paganini-Hill: DO NOT have relevant financial relationships | Jin Kyung Kim: No Answer | Mark Fisher: DO NOT have relevant financial relationships
Meeting Info:
Session Info:

Risk Factors and Prevention Posters I

Wednesday, 02/05/2025 , 07:00PM - 07:30PM

Poster Abstract Session

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