Abstract Body: Obesity is a chronic disease and is currently recognized as a global public health issue. Excess adiposity leads to metabolic and cardiovascular dysfunctions, including arterial hypertension (HTN) and cardiorenal alterations. The mechanisms underlying HTN in obesity are not yet fully understood but may involve changes in adipokine secretion and autonomic imbalance. Furthermore, few studies have investigated the cardiorenal outcomes associated with obesity. Animal models provide a valuable tool for in-depth analysis of these conditions. Hypothesis: The combination of sodium oxalate (OXA) gavage and a high-fat diet (HFD) induces metabolic disturbances, HTN, and cardiorenal alterations in male C57Bl/6 mice. Methods: Over a 12-week period, fifteen 16-week-old male C57Bl/6 mice were randomized into the following groups: CTRL (n=5), which received a standard diet and distilled water gavage; and OXA+HFD (n=10), which received a diet containing 60% fat and OXA gavage. Food intake and body weight were measured weekly. Echocardiography and metabolic cage assessments were performed at the end of the gavage period and after the protocol. Additional evaluations, including glucose tolerance testing, magnetic resonance imaging, autonomic modulation assessment, and tissue collection, were conducted at the end of the study. Pilot Results: The OXA+HFD group developed obesity (body fat mass percentage ± SEM, after 10 weeks of protocol: CTRL: 11.37% ± 0.64 vs. OXA+HFD: 28.11% ± 0.72, p<0.0001), glucose intolerance, autonomic dysfunction, proteinuria, reduced creatinine clearance, decreased cardiac ejection fraction, and cardiac and renal hypertrophy compared to the CTRL group (mean heart weight± SEM: CTRL: 6.16mg/mm±0.41 vs. OXA+HFD: 7.27mg/mm±0.12, p<0.01; mean total renal mass± SEM: CTRL: 17.63mg/mm±0.97 vs. OXA+HFD: 21.13mg/mm±0.55, p<0.01). Conclusion: OXA gavage and HFD combination induced obesity with associated metabolic, autonomic, and cardiorenal dysfunctions in male C57Bl/6 mice.