Abstract Body: Climate change is widely recognized as a significant factor impacting cardiovascular diseases , yet a detailed and comprehensive understanding of this relationship remains underdeveloped. Aim: This study aims to provide a thorough review of the current epidemiological evidence regarding how climate change affects cardiovascular diseases. Method: Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, population-based epidemiological studies focused on climate change and cardiovascular diseases were collected from Google Scholar up to January 2023. A Bibliometric analysis was conducted to describe the basic bibliographic information of the included studies. Due to methodological reasons, a meta-analysis was not performed. Results: A total of 308 relevant studies were identified from 46,200 search records that met the specified criteria, with the USA, China, and Australia being the leading contributors in this field. These studies identified 208 unique pathways through which climate change influences the morbidity and mortality of cardiovascular diseases. Key climate factors such as heatwaves, cold spells, dust storms, air pollution, wildfires, and hurricanes were found to significantly increase the risk of cardiovascular diseases. Among these, temperature change emerged as the most extensively studied topic. Conclusion: Cardiovascular disease can be exacerbated by various climate hazards, underscoring the need for more controlled and high-quality research to further explore these hazardous effects and interventions. Moreover, further measures are needed to mitigate extreme climate changes and reduce their impact on cardiovascular health.