EPI/Lifestyle 2025 Scientific Sessions  /  PS02.19 Social Determinates of Health  /  Contributions of life-course socioeconomic position to later-life MRI measures of vascular brain injury: Results from SOL-INCA-MRI
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American Heart Association

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Final ID: P2162

Contributions of life-course socioeconomic position to later-life MRI measures of vascular brain injury: Results from SOL-INCA-MRI

Abstract Body: Introduction: Cardiovascular and brain health are closely related. Increasing research has shown that cumulative exposure to low socioeconomic position (SEP) over the life-course increases the burden of poor cardiovascular and brain health. However, the influence of life-course SEP in later-life measures of vascular brain injury has rarely been evaluated

Hypothesis: Life-course SEP is associated with white matter hyperintensity volume-WMHV and brain infarcts, two magnetic resonance imaging-MRI derived measures of vascular brain injury

Methods: We used data from adults aged 50-85 years (n=2400) of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL-INCA-MRI), a population-based cohort study in the U.S. Participants' self-reports of their parental educational attainment was used as a proxy for childhood SEP (
Results: Hispanic/Latinos with higher adult SEP at visit 2 had -0.25 (-0.46, -0.04) log-WMHV relative to those with lower SEP. Similarly, adults with upward socioeconomic mobility had -0.24 (-0.47, -0.02) log-WMHV relative to those with stable low SEP. We did not find associations between childhood or adult SEP at visit 1, downward or stable high SEP with log-WMHV. No associations were found between measures of life-course SEP and brain infarcts, except for upward socioeconomic mobility (OR: 0.52 [0.27, 1.00])

Conclusion: This study shows that, among U.S. Hispanic/Latinos, higher adult SEP at visit 2 and upward socioeconomic mobility have a positive influence on WMHV or brain infarcts, highlighting the benefits of an advantageous life-course SEP on measures of vascular brain injury. This study also suggests that vascular brain injury is mostly influenced by stressors in later adulthood rather than in early life
  • Filigrana, Paola  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Marquine, Maria  ( Duke University Medical Center , Durham , North Carolina , United States )
  • Perreira, Krista  ( University of North Carolina School , Chapel Hill , North Carolina , United States )
  • Stickel, Ariana  ( San Diego State University , San Diego , California , United States )
  • Testai, Fernando  ( UNIVERSITY OF ILLINOIS AT CHIC , Chicago , Illinois , United States )
  • Decarli, Charles  ( UCDMC , Sacramento , California , United States )
  • Isasi, Carmen  ( ALBERT EINSTEIN COLLEGE MEDICINE , Bronx , New York , United States )
  • Moon, Jee-young  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Gallo, Linda  ( San Diego State University , Chula Vista , California , United States )
  • Gonzalez, Hector  ( University of California at San Diego , San Diego , California , United States )
  • Lipton, Richard  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Tarraf, Wassim  ( Wayne State University , Detroit , Michigan , United States )
  • Cai, Jianwen  ( UNC Chapel Hill , Chapel Hill , North Carolina , United States )
  • Daviglus, Martha  ( UNIVERSITY ILLINOIS CHICAGO , Chicago , Illinois , United States )
  • Kaplan, Robert  ( Albert Einstein College of Medicine , Bronx , New York , United States )
    • Author Disclosures:
    Paola Filigrana: DO NOT have relevant financial relationships | Maria Marquine: No Answer | Krista Perreira: No Answer | Ariana Stickel: No Answer | Fernando Testai: No Answer | Charles DeCarli: DO NOT have relevant financial relationships | Carmen Isasi: DO NOT have relevant financial relationships | Jee-young Moon: DO NOT have relevant financial relationships | Linda Gallo: DO NOT have relevant financial relationships | Hector Gonzalez: No Answer | Richard Lipton: No Answer | Wassim Tarraf: No Answer | Jianwen Cai: No Answer | Martha Daviglus: DO NOT have relevant financial relationships | Robert Kaplan: No Answer
Meeting Info:

EPI/Lifestyle 2025 Scientific Sessions

2025

New Orleans, LA

Session Info:

PS02.19 Social Determinates of Health

Friday, 03/07/2025 , 05:00PM - 07:00PM

Poster Session

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