EPI/Lifestyle 2025 Scientific Sessions  /  PS02.19 Social Determinates of Health  /  Contributions of life-course socioeconomic position to later-life MRI measures of vascular brain injury: Results from SOL-INCA-MRI
Logo

American Heart Association

  161
  0

Final ID: P2162

Contributions of life-course socioeconomic position to later-life MRI measures of vascular brain injury: Results from SOL-INCA-MRI

Abstract Body: Introduction: Cardiovascular and brain health are closely related. Increasing research has shown that cumulative exposure to low socioeconomic position (SEP) over the life-course increases the burden of poor cardiovascular and brain health. However, the influence of life-course SEP in later-life measures of vascular brain injury has rarely been evaluated

Hypothesis: Life-course SEP is associated with white matter hyperintensity volume-WMHV and brain infarcts, two magnetic resonance imaging-MRI derived measures of vascular brain injury

Methods: We used data from adults aged 50-85 years (n=2400) of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL-INCA-MRI), a population-based cohort study in the U.S. Participants' self-reports of their parental educational attainment was used as a proxy for childhood SEP (
Results: Hispanic/Latinos with higher adult SEP at visit 2 had -0.25 (-0.46, -0.04) log-WMHV relative to those with lower SEP. Similarly, adults with upward socioeconomic mobility had -0.24 (-0.47, -0.02) log-WMHV relative to those with stable low SEP. We did not find associations between childhood or adult SEP at visit 1, downward or stable high SEP with log-WMHV. No associations were found between measures of life-course SEP and brain infarcts, except for upward socioeconomic mobility (OR: 0.52 [0.27, 1.00])

Conclusion: This study shows that, among U.S. Hispanic/Latinos, higher adult SEP at visit 2 and upward socioeconomic mobility have a positive influence on WMHV or brain infarcts, highlighting the benefits of an advantageous life-course SEP on measures of vascular brain injury. This study also suggests that vascular brain injury is mostly influenced by stressors in later adulthood rather than in early life
  • Filigrana, Paola  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Marquine, Maria  ( Duke University Medical Center , Durham , North Carolina , United States )
  • Perreira, Krista  ( University of North Carolina School , Chapel Hill , North Carolina , United States )
  • Stickel, Ariana  ( San Diego State University , San Diego , California , United States )
  • Testai, Fernando  ( UNIVERSITY OF ILLINOIS AT CHIC , Chicago , Illinois , United States )
  • Decarli, Charles  ( UCDMC , Sacramento , California , United States )
  • Isasi, Carmen  ( ALBERT EINSTEIN COLLEGE MEDICINE , Bronx , New York , United States )
  • Moon, Jee-young  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Gallo, Linda  ( San Diego State University , Chula Vista , California , United States )
  • Gonzalez, Hector  ( University of California at San Diego , San Diego , California , United States )
  • Lipton, Richard  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Tarraf, Wassim  ( Wayne State University , Detroit , Michigan , United States )
  • Cai, Jianwen  ( UNC Chapel Hill , Chapel Hill , North Carolina , United States )
  • Daviglus, Martha  ( UNIVERSITY ILLINOIS CHICAGO , Chicago , Illinois , United States )
  • Kaplan, Robert  ( Albert Einstein College of Medicine , Bronx , New York , United States )
    • Author Disclosures:
    Paola Filigrana: DO NOT have relevant financial relationships | Maria Marquine: No Answer | Krista Perreira: No Answer | Ariana Stickel: No Answer | Fernando Testai: No Answer | Charles DeCarli: DO NOT have relevant financial relationships | Carmen Isasi: DO NOT have relevant financial relationships | Jee-young Moon: DO NOT have relevant financial relationships | Linda Gallo: DO NOT have relevant financial relationships | Hector Gonzalez: No Answer | Richard Lipton: No Answer | Wassim Tarraf: No Answer | Jianwen Cai: No Answer | Martha Daviglus: DO NOT have relevant financial relationships | Robert Kaplan: No Answer
Meeting Info:

EPI/Lifestyle 2025 Scientific Sessions

2025

New Orleans, LA

Session Info:

PS02.19 Social Determinates of Health

Friday, 03/07/2025 , 05:00PM - 07:00PM

Poster Session

More abstracts on this topic:
A Multicenter Study of Detection of Pulmonary Hypertension Based on Point-of-Care 12- Lead ECG Data

Dubrock Hilary, Wieczorek Mikolaj, Hackett Sarah, Alger Heather, Carlson Katherine, Klugherz Paul, Carter Rickey, Wagner Tyler, Johnson Patrick, Frantz Robert, Strom Jordan, Waks Jonathan, Agarwal Richa, Hemnes Anna, Steinberg Benjamin, Pandey Ambarish

A Quarter Century of Mortality Trends in Hypertension and Sick Sinus Syndrome Among Elderly in the United States

Eltawansy Sherif, Khan Muhammad, Iqbal Asad, Sharif Aleena, Hossain Mohammad, Ali Muhammad Faizan, Ahmad Husnain, Faizan Muhammad, Ahmed Ashraf, Abdul Malik Mohammad Hamza Bin, Pahwani Ritesh, Patel Rahul, Mehdi Hassan

More abstracts from these authors:
Genetics of Cerebral White Matter Hyperintensities in Diverse Hispanic/Latino Adults

Fornage Myriam, Sofer Tamar, Isasi Carmen, Lipton Richard, Stickel Ariana, Tarraf Wassim, Gonzalez Hector, Decarli Charles

Non-genetic component of height as a surrogate marker for childhood socioeconomic status and its association with cardiovascular and brain health: results from HCHS/SOL

Moon Jee-young, Qi Qibin, Thyagarajan Bharat, Tarraf Wassim, Wang Tao, Isasi Carmen, Filigrana Paola, Gallo Linda, Perreira Krista, Cai Jianwen, Daviglus Martha, Fernandez-rhodes Lindsay, Garcia-bedoya Olga, Kaplan Robert

You have to be authorized to contact abstract author. Please, Login
Not Available