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American Heart Association

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Final ID: MP1186

Evaluating the Therapeutic Potential of Cord-Derived Stem Cells in Hypoplastic Left Heart Syndrome: A Comparative Analysis

Abstract Body (Do not enter title and authors here): Background:
Hypoplastic Left Heart Syndrome (HLHS) is a severe congenital heart defect, representing approximately 2–4% of all congenital heart diseases and accounting for 23% of neonatal cardiac deaths. Umbilical cord-derived hematopoietic stem cell (HSCs) therapy has emerged as a promising therapy. The therapy has the potential for cardiac regeneration via differentiation, paracrine signaling, and immunomodulation.
Compared to bone marrow or embryonic sources, umbilical cord cells are ethically obtained, non-invasively collected, and exhibit low immunogenicity.
Hypothesis:
Early administration of umbilical cord-derived HSCs in HLHS may enhance myocardial recovery, reduce postoperative complications, and support long-term cardiac function.
Methodology:
This study aims to evaluate clinical trials involving post-operative intramyocardial delivery of autologous umbilical cord-derived HSCs in HLHS patients. Effectiveness has been analyzed using the right ventricular ejection fraction (RVEF) measures.
Results:
The studies have shown that HLHS infants receiving HSCs therapy have shown a significant improvement in RVEF up to 7.1% in 18 months. At 36 months, the RVEF was reported to be improved by 8.0%. The therapy was well-tolerated with no major adverse events.
Conclusion:
Umbilical cord-derived HSCs therapy is a promising therapy in infants with its regenerative and cardioprotective potentials. Long-term safety profile and the personalized treatment protocol need large-scale randomized clinical trials.
  • Shenoy, Aditi  ( D. Y. Patil University School of Medicine, Mumbai, India , Mumbai , India )
  • Samardali, Dana  ( Faculty of Medicine ,Yarmouk University, Irbid,Jordan , Irbid , Jordan )
  • Shetty D H, Kavana  ( Adichunchanagiri Institute of Medical Sciences , Karnataka, India , India , India )
  • Sathi Prakasan, Dilan  ( Tbilisi state medical university , Georgia , Georgia )
  • ---, Srijamya  ( Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia , Georgia , Georgia )
  • Author Disclosures:
    Aditi Shenoy: DO NOT have relevant financial relationships | Dana Samardali: DO NOT have relevant financial relationships | Kavana Shetty D H: DO NOT have relevant financial relationships | Dilan Sathi prakasan: DO NOT have relevant financial relationships | Srijamya ---: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2025

2025

New Orleans, Louisiana

Session Info:

Tissue Engineering & Cellular Regeneration

Saturday, 11/08/2025 , 01:45PM - 02:55PM

Moderated Digital Poster Session

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