Scientific Sessions 2025  /  New Discoveries in Clinical Hypertension Research  /  Associations Between Calcium-Phosphate Ratio and Blood Pressure in Non-CKD Populations
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American Heart Association

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Final ID: MP361

Associations Between Calcium-Phosphate Ratio and Blood Pressure in Non-CKD Populations

Abstract Body (Do not enter title and authors here): Introduction: Serum calcium, phosphate, and their interaction have been linked to vascular calcification. While high calcium-phosphate ratio (Ca/P) has been associated with adverse cardiovascular outcomes especially in chronic kidney disease (CKD), its relationship with blood pressure in non-CKD remains unclear. This study aims to assess the association between Ca/P and blood pressure in individuals without CKD.
Methods: A retrospective cross-sectional analysis was conducted using data from the 2017–2020 NHANES. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were calculated from 3 consecutive blood pressure measurements. Ca/P was calculated by dividing serum calcium by serum phosphate (mg/dL) and categorized into quartiles. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI formula, with non-CKD defined as eGFR ≥ 60 mL/min/1.73 m2. Associations of serum calcium, phosphate, and Ca/P with SBP and DBP were assessed using multiple linear regression models, adjusting for demographics, comorbidities, laboratory values, average sodium and alcohol intake, and socioeconomic status.
Result: Among the 4,621 adults included, mean age±SD was 51±17 years and 91.6% was non-CKD. The mean SBP and DBP were 124±19 and 75±11mmHg, respectively. The mean serum calcium and phosphate were 9.3±0.4 and 3.6±0.5 mg/dL, and the median [IQR] Ca/P was 2.6 [2.4–2.9]. In the fully adjusted models, serum Ca/P and calcium were positively associated with mean SBP and DBP while serum phosphate showed an inverse association (all p<0.05). When Ca/P was categorized into quartiles, Q3 and Q4 were graded associated with higher SBP (aβSBP-Q3 2.31 (0.97-3.65) p<0.01, aβSBP-Q4 2.79 (1.39-4.19) p<0.01) and DBP (aβDBP-Q3 1.35 (0.51-2.20) p<0.01, aβDBP-Q4 1.71 (0.82-2.59) p<0.01). In subgroup analysis of non-CKD, Ca/P in Q3 and Q4 showed stronger associations with both higher SBP (aβnon-CKD/SBP-Q3 2.64 (1.31-3.67) p<0.01, aβnon-CKD/SBP-Q4 3.29 (1.89-4.69) p<0.01) and DBP (aβnon-CKD/DBP-Q3 1.42 (0.55-2.28) p<0.01, aβnon-CKD/DBP-Q4 1.80 (0.90-2.70) p<0.01).
Conclusion: Our study demonstrated that higher Ca/P is associated with elevated blood pressure, even in individuals without CKD. This hilights the need for further investigation into the interaction between serum calcium and phosphate in the non-CKD populations.
  • Yongkiatkan, Panchanit  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Wongmat, Napat  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Chamnarnphol, Natanon  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Puyati, Weerinth  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Wareesawetsuwan, Nicha  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Ngaohirunpat, Sorawis  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Noree, Wanprapit  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Mohpichai, Nopavit  ( Mahidol University , Bangkok , Thailand )
  • Gangeddula, Vishwaas  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Kim, Seonghyeon  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Massihians, Monique  ( Joe C. Wen School of Population & Public Health, University of California Irvine , Irvine , California , United States )
  • Lapadjyan, Mary  ( Joe C. Wen School of Population & Public Health, University of California Irvine , Irvine , California , United States )
  • Shahnazarian, Christine  ( Joe C. Wen School of Population & Public Health, University of California Irvine , Irvine , California , United States )
  • Liu, Yangjiayi  ( Joe C. Wen School of Population & Public Health, University of California Irvine , Irvine , California , United States )
  • Park, David  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Ho, Meghan  ( Joe C. Wen School of Population & Public Health, University of California Irvine , Irvine , California , United States )
  • Ghaffarian, Bahaar  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Lee, Sarah  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Le, Vanessa  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Vutthikraivit, Possawat  ( MedPark Hospital , Bangkok , Thailand )
  • Bunyawannukul, Issaree  ( Faculty of medicine, Khon Kaen univ , Sakonnakhon , Thailand )
  • Kookanok, Chutawat  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Kulthamrongsri, Narathorn  ( University of Hawaii Internal Medicine Residency Program, University of Hawaii John A. Burns School of Medicine , Honolulu , Hawaii , United States )
  • Wattanachayakul, Phuuwadith  ( Albert Einstein Medical Center , Philadelphia , Pennsylvania , United States )
  • Lee, Kyunghee  ( University of California Irvine School of Medicine , Orange , California , United States )
  • Tantisattamo, Ekamol  ( University of California Irvine School of Medicine , Orange , California , United States )
    • Author Disclosures:
    Panchanit Yongkiatkan: DO NOT have relevant financial relationships | Seonghyeon Kim: DO NOT have relevant financial relationships | Monique Massihians: No Answer | Mary Lapadjyan: No Answer | Christine Shahnazarian: No Answer | Yangjiayi Liu: No Answer | David Park: No Answer | Meghan Ho: No Answer | Bahaar Ghaffarian: DO NOT have relevant financial relationships | Sarah Lee: No Answer | Vanessa Le: DO NOT have relevant financial relationships | Napat Wongmat: DO NOT have relevant financial relationships | Possawat Vutthikraivit: No Answer | Issaree Bunyawannukul: DO NOT have relevant financial relationships | Chutawat KOOKANOK: DO NOT have relevant financial relationships | Narathorn Kulthamrongsri: DO NOT have relevant financial relationships | Phuuwadith Wattanachayakul: No Answer | Kyunghee Lee: DO NOT have relevant financial relationships | Ekamol Tantisattamo: DO NOT have relevant financial relationships | Natanon Chamnarnphol: DO NOT have relevant financial relationships | Weerinth Puyati: DO NOT have relevant financial relationships | Nicha Wareesawetsuwan: DO NOT have relevant financial relationships | Sorawis Ngaohirunpat: No Answer | Wanprapit Noree: DO NOT have relevant financial relationships | Nopavit Mohpichai: DO NOT have relevant financial relationships | Vishwaas Gangeddula: No Answer
Meeting Info:

Scientific Sessions 2025

2025

New Orleans, Louisiana

Session Info:

New Discoveries in Clinical Hypertension Research

Saturday, 11/08/2025 , 01:45PM - 02:45PM

Moderated Digital Poster Session

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