Scientific Sessions 2025  /  Heart Failure in CKM Syndrome: Prevention, Management and Outcomes  /  Trends in Nonalcoholic Steatohepatitis and Congestive Heart Failure Mortality in the United States from 1999 to 2020: A Comprehensive Analysis
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American Heart Association

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Final ID: MP2234

Trends in Nonalcoholic Steatohepatitis and Congestive Heart Failure Mortality in the United States from 1999 to 2020: A Comprehensive Analysis

Abstract Body (Do not enter title and authors here):

Background:
Metabolic-dysfunction associated steatohepatitis (MASH), previously nonalcoholic steatohepatitis (NASH), and congestive heart failure (CHF) are rising public health concerns in the U.S. This study evaluates trends in age-adjusted mortality rates (AAMR) for NASH and CHF from 1999 to 2020.
Methods:
CHF-related deaths in patients with pre-existing NASH from 1999 to 2020 were obtained from the CDC WONDER database. AAMR per million population were calculated. Trends were analyzed using average annual percentage change (AAPC) and joinpoint regression.
Results:
From 1999 to 2020, NASH and CHF caused 68,436 deaths in the U.S. AAMR increased from 12.49 per million (95% CI 11.97-13.01) in 1999 to 29.25 per million (95% CI 23.71-24.9) in 2020. Mortality rates declined from 1999 to 2010 (APC -1.49; 95% CI -2.23 to -0.89, p=0.003) but surged from 2017 to 2020 (APC 12.35; 95% CI 9.70-15.98, p=0.010). The overall AAPC was 3.05% (95% CI 2.79-3.30, p<0.0001).
Conclusion:
This analysis shows a concerning increase in NASH and CHF-related mortality in recent years. The rise in mortality highlights the need for targeted clinical interventions and public health strategies to mitigate the burden of these diseases.
  • Plunkett, Ryan  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Bedi, Rohil  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Golemi, Lolita  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Khorsandi, Michael  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Peters, John  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Okeke, Barbara  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Rogers, Lanerica  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Rojulpote, Chaitanya  ( Brigham and Women's Hospital , Boston , Massachusetts , United States )
  • Mikhalkova, Deana  ( Saint Louis University , Saint Louis , Missouri , United States )
  • Qureshi, Kamran  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Lin, Chien-jung  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Ahmed, Faizan  ( Duke University Hospital , Durham , North Carolina , United States )
  • Philip, Nicholas  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Taha, Isra  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Desai, Nitin  ( Saint Louis University , Saint Louis , Missouri , United States )
  • Stein, Eric  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Thomas, Alexander  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Rotramel, Hayden  ( Saint Louis University Hospital , Saint louis , Missouri , United States )
  • Raja Sager, Avinaash  ( Boston Medical Center , Boston , Massachusetts , United States )
    • Author Disclosures:
    ryan plunkett: No Answer | Rohil Bedi: DO NOT have relevant financial relationships | Lolita Golemi: No Answer | Michael Khorsandi: No Answer | John Peters: No Answer | Barbara Okeke: No Answer | Lanerica Rogers: DO NOT have relevant financial relationships | Chaitanya Rojulpote: DO NOT have relevant financial relationships | Deana Mikhalkova: No Answer | Kamran Qureshi: No Answer | Chien-Jung Lin: DO have relevant financial relationships ; Other (please indicate in the box next to the company name):Boston Scientific:Past (completed) | Faizan Ahmed: DO NOT have relevant financial relationships | Nicholas Philip: DO NOT have relevant financial relationships | Isra Taha: DO NOT have relevant financial relationships | Nitin Desai: DO NOT have relevant financial relationships | Eric Stein: DO NOT have relevant financial relationships | Alexander Thomas: No Answer | Hayden Rotramel: No Answer | Avinaash Raja Sager: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2025

2025

New Orleans, Louisiana

Session Info:

Heart Failure in CKM Syndrome: Prevention, Management and Outcomes

Monday, 11/10/2025 , 01:45PM - 02:55PM

Moderated Digital Poster Session

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