Scientific Sessions 2025  /  Cardiovascular Nutrition: From Nutrients to Dietary Patterns  /  The Effect and Safety of Ketogenic Diets on LDL-C and other metabolic parameters compared with non-ketogenic diets among Adults with BMI Greater than 25 with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
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American Heart Association

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Final ID: Mo2085

The Effect and Safety of Ketogenic Diets on LDL-C and other metabolic parameters compared with non-ketogenic diets among Adults with BMI Greater than 25 with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Abstract Body (Do not enter title and authors here):
OBJECTIVE
To determine the effects of a ketogenic diet on LDL-C levels and other metabolic parameters and adverse events in adults with a BMI greater than 25 and type 2 diabetes mellitus.
METHODS
A systematic review and meta-analysis of randomized controlled trials was conducted. Studies were identified through thorough searches of PubMed, Cochrane, Google Scholar, EMBASE, HERDIN. Included studies compared a ketogenic diet (≤10% carbohydrates) to a non-ketogenic diet for at least 3 months duration in adults with a BMI ≥25 and type 2 diabetes. The primary outcome was LDL-C level. Risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool and GRADE guidelines.
RESULTS
Nine studies with a total of 658 participants were included. In the short term (3-4 months), ketogenic diets significantly reduced LDL-C compared to non-ketogenic diets (mean difference: -0.16 mmol/L, 95% CI -0.31, -0.00, p = 0.04). This effect was not significant at longer follow-up periods (6-8 months, 12 months, and 24 months). Common adverse effects included hypoglycemia, constipation, and gastrointestinal discomfort.
CONCLUSION:
Ketogenic diets may offer short-term benefits in reducing LDL-C in overweight and obese adults with type 2 diabetes. However, these effects diminish over time, and the diet may be associated with adverse events. Significant short-term improvements were observed in HDL-C, triglycerides (TG), and HbA1c in ketogenic groups compared to controls, with moderate effects diminishing over time. Notably, follow-up time was a significant moderator for HDL-C, showing stronger effects at later time points, while FBS showed a borderline significant relationship with follow-up Long-term studies evaluating a broader range of metabolic outcomes are needed.
  • Supe, Anya Francheska  ( Cardinal Santos Medical Center , Quezon City , Philippines )
  • San Juan, Albert  ( Cardinal Santos Medical Center , Quezon City , Philippines )
  • Sy, Rosa  ( CARDINAL SANTOS MEDICAL CENTER , Metro Manila , Philippines )
  • Chiu, Harold Henrison  ( Cardinal Santos Medical Center , Quezon City , Philippines )
    • Author Disclosures:
    Anya Francheska Supe: DO NOT have relevant financial relationships | Albert San Juan: DO NOT have relevant financial relationships | Rosa Sy: No Answer | Harold Henrison Chiu: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2025

2025

New Orleans, Louisiana

Session Info:

Cardiovascular Nutrition: From Nutrients to Dietary Patterns

Monday, 11/10/2025 , 10:30AM - 11:30AM

Abstract Poster Board Session

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