Scientific Sessions 2024  /  Best of AHA Specialty Conferences: EPI/Lifestyle 2024  /  Life-course socioeconomic status and the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

American Heart Association

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Final ID: EPI12

Life-course socioeconomic status and the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Abstract Body (Do not enter title and authors here): Introduction: Socioeconomic status (SES) in childhood and beyond may influence the gut microbiome (GMB), with implications for disease risk. Studies evaluating the relationship between life-course SES and the gut microbiome (GMB) are sparse, particularly among Hispanic/Latino individuals, who have a high prevalence of low SES.
Hypothesis: Low life-course SES indicators are associated with less diversity and overall composition of the gut microbiome in Hispanic/Latino adults.
Methods: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multi-site population-based cohort study conducted in the U.S. We examined 2540 participants (18 to 74 years) with SES and gut microbiome information. Childhood SES (n=2274) and adult SES (n=2412) were used as SES indicators. We used the highest education achieved by the father or mother and classified it as a lower (Results: Childhood and adult SES were not associated with the Shannon diversity index. Childhood and adult SES were associated with the overall gut microbiome composition; however, childhood SES explained more the gut microbiome variance than adult SES. Lower childhood SES was associated with 38 species and lower adult SES with 5 species. A lower childhood and adult SES were associated with a lower abundance of species from genus Bacteroides.
Conclusion: A lower childhood SES was associated with an altered GMB composition in U.S. Hispanic/Latino adults. Early-life SES may have long-term effects on GMB composition, underscoring another biological mechanism linking early childhood factors to adulthood disease.
  • Batalha, Monica  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Mcclain, Amanda  ( San Diego State University , San Diego , California , United States )
  • Thyagarajan, Bharat  ( University of Minnesota , Minneapolis , Minnesota , United States )
  • Daviglus, Martha  ( University of Illinois at Chicago , Chicago , Illinois , United States )
  • Hou, Lifang  ( Northwestern University , Chicago , Illinois , United States )
  • Llabre, Maria  ( University of Miami , Miami , Florida , United States )
  • Cai, Jianwen  ( University of North Carolina at Chapel Hill , Chapel Hill , North Carolina , United States )
  • Kaplan, Robert  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Isasi, Carmen  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Lecroy, Madison  ( NYU Grossman School of Medicine , New York City , New York , United States )
  • Lin, Juan  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Peters-samuelson, Brandilyn  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Qi, Qibin  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Wang, Zheng  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Wang, Tao  ( Albert Einstein College of Medicine , Bronx , New York , United States )
  • Gallo, Linda  ( San Diego State University , San Diego , California , United States )
  • Talavera, Gregory  ( San Diego State University , San Diego , California , United States )
    • Author Disclosures:
    Monica Batalha: DO NOT have relevant financial relationships | Amanda McClain: DO NOT have relevant financial relationships | Bharat Thyagarajan: No Answer | Martha Daviglus: DO NOT have relevant financial relationships | Lifang Hou: DO NOT have relevant financial relationships | Maria Llabre: No Answer | Jianwen Cai: DO NOT have relevant financial relationships | Robert Kaplan: No Answer | Carmen Isasi: DO NOT have relevant financial relationships | Madison LeCroy: DO NOT have relevant financial relationships | Juan Lin: No Answer | Brandilyn Peters-Samuelson: DO NOT have relevant financial relationships | Qibin Qi: DO NOT have relevant financial relationships | Zheng Wang: No Answer | Tao Wang: DO NOT have relevant financial relationships | Linda Gallo: DO NOT have relevant financial relationships | Gregory Talavera: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Best of AHA Specialty Conferences: EPI/Lifestyle 2024

Monday, 11/18/2024 , 10:30AM - 11:30AM

Best of Specialty Conferences

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