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American Heart Association

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Final ID: MDP1100

Trends, Prevalence of Bradyarrhythmia and Pacemaker Implantation in Patients with Parkinson’s Disease.

Abstract Body (Do not enter title and authors here): Background: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, affecting more than one million persons in the United States. Cardiovascular dysautonomia is a prominent dysfunction in PD, affecting the conduction system and causing bradyarrhythmia. However, no studies have assessed the prevalence and characteristics of bradyarrhythmia in patients with PD.

Research Question: Is there an increased prevalence of bradyarrhythmia and pacemaker implantation in patients with PD?

Aims: The study assessed the trends, prevalence, and risk factors of bradyarrhythmia and pacemaker implantation in PD patients.

Methods: The National Inpatient Sample was utilized to identify patients' data with primary and secondary diagnoses of Parkinson’s disease (PD) in the United States from 2016 to 2020 using the International Classification of Disease, 10th Revision codes. Outcomes of interest included the trends and prevalence of bradyarrhythmia and pacemaker implantation in PD. We assessed potential predictors of bradyarrhythmia in patients with PD using a backward selection multivariable logistic regression.

Results: A total of 333,242 patients with PD diagnosis were included (76.5 ± 15.2 years, 58.7% male, 80.1% white); of these, 5,092 (20.5%) had comorbid diagnoses of bradyarrhythmia, and 328,150 (79.5%) without bradyarrhythmia. The prevalence of bradyarrhythmia in patients with PD was 351.9 per 10,000 hospitalizations (3.5%). The trends of bradyarrhythmia showed a stable increase from 291.9 to 463.8 per 10,000 (AAPC 12.5%, CI: -0.2%, 26.8%). The overall prevalence of pacemaker implantation in patients with PD was 79.9 per 10,000 hospitalizations (0.8%). The overall trends of pacemaker implantation showed a stable decrease in patients with PD during 2016-2020, with an AAPC -0.9% (CI: -4.1% to 2.3%). Age≥ 65, male sex, comorbidities (atrial fibrillation, coronary artery disease, heart failure, hypertension, liver failure, obesity, peripheral vascular disease, renal failure) were associated with a higher likelihood of bradyarrhythmia in patients with PD.

Conclusions: This study's findings revealed that the prevalence of bradyarrhythmia and subsequent pacemaker implantation in patients with PD remained relatively stable over the study period. The study provides the initial prevalence of bradyarrhythmia in patients with Parkinson’s disease. Further study is necessary to provide the characteristics and outcomes of bradyarrhythmia in PD.
  • Nzeako, Tochukwu  ( Christiana care Hospital , Newark , Delaware , United States )
  • Adeniran, Olayemi  ( SUNY Downstate University Hospital , Brooklyn , New York , United States )
  • Singh, Shreya  ( Touro College of Osteopathic Medicine , Manhattan , New York , United States )
  • Kaur, Saranjeet  ( Touro College of Osteopathic Medicine , Manhattan , New York , United States )
  • Ukenenye, Emmanuel  ( Brookdale University Hospital Medical Center , New York , New York , United States )
  • Wimmer, Neil  ( Christiana Care Hospital , Newark , Delaware , United States )
  • Author Disclosures:
    Tochukwu Nzeako: DO NOT have relevant financial relationships | Olayemi Adeniran: DO NOT have relevant financial relationships | Shreya Singh: No Answer | Saranjeet Kaur: DO NOT have relevant financial relationships | Emmanuel Ukenenye: DO NOT have relevant financial relationships | Neil Wimmer: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Cardiovascular Disease and Neurocognitive Health: Exploring the Vital Link for Optimal Well-Being

Sunday, 11/17/2024 , 03:15PM - 04:30PM

Moderated Digital Poster Session

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