Scientific Sessions 2024
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All Things Mitral!
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Impact of Nutritional Status on Transcatheter Edge-to-Edge Repair Outcomes in Mitral Regurgitation: Insights from a National Database Analysis
American Heart Association
2
0
Final ID: Sa4099
Impact of Nutritional Status on Transcatheter Edge-to-Edge Repair Outcomes in Mitral Regurgitation: Insights from a National Database Analysis
Abstract Body (Do not enter title and authors here):
Introduction: Transcatheter edge-to-edge repair of the mitral valve with the MitraClip has offered a less invasive percutaneous alternative to surgical repair in select candidates with mitral regurgitation. Various factors impact the outcomes of MitraClip. We investigated the impact of nutritional status on the outcomes of MitraClip. Methods: Utilizing the nationwide inpatient sample data for years from January 1, 2016, and December 31, 2021, patients who underwent MitraClip were identified. They were categorized based on obesity and protein energy malnutrition (PEM). Statistical significance was assigned at p<05. Results: Out of the 8115 patients undergoing MitraClip, 2215 had PEM, and 5900 had obesity—table 1. Patients in the PEM group were older, with a higher prevalence of comorbidities, including anemia, pneumonia, liver disease, and fluid and electrolyte disorders, compared to the obese group. Conversely, the obesity group had a higher prevalence of hypertension, diabetes, and hypertension with complications. Our analysis revealed that PEM subgroups had significantly higher in-hospital mortality, cardiogenic shock, mechanical circulatory support (MCS) requirement, post-procedural worsening heart failure, spontaneous cardiac arrest, and major adverse cardiovascular and cerebrovascular events (MACCE). After adjusting for potential confounders, PEM remained an independent predictor of increased odds of death, cardiac arrest, ECMO, MCS, and MACCE compared to obesity. The propensity score matching analysis confirmed that PEM was associated with significantly higher rates of in-hospital mortality, cardiac arrest, and MACCE compared to obesity. (Figure 1) Conclusion Our results reveal that PEM is associated with significantly worse outcomes in patients undergoing MitraClip procedures compared to obesity. These findings are consistent across multivariate and propensity score matching analyses.
Bolaji, Olayiwola
( Rutgers University New Jersey Medic
, Newark
, New Jersey
, United States
)
Alraies, M Chadi
( Detroit Medical Center
, Detroit
, Michigan
, United States
)
Haider, Mobeen
( Carle Foundation Hospital
, Champaign
, Illinois
, United States
)
Upreti, Prakash
( Sands-Constellation Heart Institute, Rochester Regional Health
, Rochester
, New York
, United States
)
Alsmairat, Yousef
( Detroit Medical Center
, Detroit
, Michigan
, United States
)
Hotwani, Priya
( Parkview Health, Fort Wayne
, FortWayne
, Indiana
, United States
)
Rajak, Kripa
( UPMC
, Harrisburg
, Pennsylvania
, United States
)
Basit, Jawad
( Rawalpindi Medical University
, Rawalpindi
, Pakistan
)
Goru, Rohit
( Wayne State University
, Detroit
, Michigan
, United States
)
Ziaullah, Abubakr
( Detroit Medical Center
, Detroit
, Michigan
, United States
)
Author Disclosures:
Olayiwola Bolaji:DO NOT have relevant financial relationships
| M Chadi Alraies:DO NOT have relevant financial relationships
| Mobeen Haider:DO NOT have relevant financial relationships
| Prakash Upreti:DO NOT have relevant financial relationships
| Yousef Alsmairat:DO NOT have relevant financial relationships
| Priya Hotwani:DO NOT have relevant financial relationships
| Kripa Rajak:DO NOT have relevant financial relationships
| Jawad Basit:DO NOT have relevant financial relationships
| Rohit Goru:DO NOT have relevant financial relationships
| Abubakr Ziaullah:DO NOT have relevant financial relationships
