Scientific Sessions 2024  /  One and Done or Three-Peat? Understanding, Predicting and Preventing Recurrence in AFib Ablation  /  Obstructive Sleep Apnea is Associated with Ablation Failure in Paroxysmal Atrial Fibrillation Patients Only: Insights from a left atrial MRI Database
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American Heart Association

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Final ID: MDP1672

Obstructive Sleep Apnea is Associated with Ablation Failure in Paroxysmal Atrial Fibrillation Patients Only: Insights from a left atrial MRI Database

Abstract Body (Do not enter title and authors here): Background: Obstructive sleep apnea (OSA) may influence the outcomes of catheter ablation in atrial fibrillation (AF) patients, but its impact at different stages of AF is not well understood.
Objective: This study aims to evaluate whether OSA influences catheter ablation outcomes differently in patients with paroxysmal AF compared to those with persistent AF.
Methods: We included AF patients with and without obstructive sleep apnea (OSA) in a late gadolinium enhancement (LGE) MRI database of patients who underwent catheter ablation. Our study population was stratified based on the type of AF: paroxysmal or persistent. Patients were followed for 24 months post-ablation, with a 3-month blanking period. To analyze time-to-AF recurrence, we used Kaplan-Meier curve along with the log-rank test to compare recurrence rates between patients with and without OSA in both AF types. Additionally, we used Cox regression analysis to adjust for potential confounders.
Results: 324 patients with paroxysmal AF (mean age: 64.5) and 512 patients with persistent AF (mean age: 65.2) were included. The left atrial (LA) volume was similar between OSA and non-OSA patients in both the paroxysmal AF cohort (83.1 mm3 vs. 83.6 mm3; p=0.73) and the persistent AF cohort (115 mm3 vs. 119 mm3; p=0.37). Patients with OSA exhibited a higher prevalence of comorbidities, including congestive heart failure (CHF), coronary artery disease, obesity, and diabetes, compared to non-OSA patients (p<0.05). After adjusting for these comorbidities, OSA was significantly associated with a higher rate of AF recurrence following ablation in paroxysmal AF patients (HR=2.249; p<0.001). However, OSA did not significantly impact ablation outcomes in persistent AF patients (HR=1.014; p=0.836).
Conclusion: OSA significantly impacts the success of catheter ablation in patients with paroxysmal atrial fibrillation (AF), leading to higher rates of AF recurrence. However, this association was not observed in patients with persistent AF.
  • Bidaoui, Ghassan  ( tulane university , New orleans , Louisiana , United States )
  • Younes, Hadi  ( Tulane University , New Orleans , Louisiana , United States )
  • Feng, Han  ( Tulane University , New Orleans , Louisiana , United States )
  • Bsoul, Mayana  ( Tulane University , New Orleans , Louisiana , United States )
  • Assaf, Ala'  ( Tulane University , New Orleans , Louisiana , United States )
  • Chouman, Nour  ( Tulane University , New Orleans , Louisiana , United States )
  • Tirado Polo, Francisco  ( Tulane University , New Orleans , Louisiana , United States )
  • Liu, Yingshuo  ( Tulane University , New Orleans , Louisiana , United States )
  • Jia, Yishi  ( Tulane University , New Orleans , Louisiana , United States )
  • Lim, Chanho  ( Tulane University , New Orleans , Louisiana , United States )
  • Hassan, Abboud  ( Tulane University , New Orleans , Louisiana , United States )
  • Hui, Yanpei  ( Tulane University , New Orleans , Louisiana , United States )
  • Tsakiris, Eli  ( Tulane University , New Orleans , Louisiana , United States )
  • Abi-rached, Joe  ( Tulane University , New Orleans , Louisiana , United States )
  • Ademi, Besim  ( Tulane University , New Orleans , Louisiana , United States )
  • Noujaim, Charbel  ( Tulane University , New Orleans , Louisiana , United States )
  • Rao, Swati  ( Tulane University , New Orleans , Louisiana , United States )
  • Kreidieh, Omar  ( Tulane University , New Orleans , Louisiana , United States )
  • Donnellan, Eoin  ( Tulane University , New Orleans , Louisiana , United States )
  • Pandey, Amitabh  ( Tulane University , New Orleans , Louisiana , United States )
  • Marrouche, Nassir  ( Tulane University , New Orleans , Louisiana , United States )
    • Author Disclosures:
    ghassan bidaoui: DO NOT have relevant financial relationships | Chanho Lim: No Answer | Abboud Hassan: No Answer | Yanpei Hui: DO NOT have relevant financial relationships | Eli Tsakiris: DO NOT have relevant financial relationships | Joe Abi-Rached: DO NOT have relevant financial relationships | Besim Ademi: DO NOT have relevant financial relationships | Charbel Noujaim: No Answer | Swati Rao: No Answer | Omar Kreidieh: No Answer | eoin donnellan: DO NOT have relevant financial relationships | Hadi Younes: DO NOT have relevant financial relationships | Amitabh Pandey: DO NOT have relevant financial relationships | Nassir Marrouche: DO have relevant financial relationships ; Consultant:Biosense Webster:Active (exists now) ; Ownership Interest:Marrek:Active (exists now) ; Research Funding (PI or named investigator):Samsung:Active (exists now) ; Research Funding (PI or named investigator):Sanofi :Active (exists now) ; Research Funding (PI or named investigator):Boston Scientific:Active (exists now) ; Research Funding (PI or named investigator):Siemens:Active (exists now) ; Research Funding (PI or named investigator):Biosense Webster:Active (exists now) ; Research Funding (PI or named investigator):Medtronic:Active (exists now) ; Research Funding (PI or named investigator):Abbott:Active (exists now) ; Speaker:Sanofi:Active (exists now) ; Speaker:AtriCure :Active (exists now) ; Speaker:Biosense Webster:Active (exists now) ; Speaker:Abbott:Active (exists now) ; Consultant:AtriCure:Active (exists now) ; Consultant:Boston Scientific :Active (exists now) | Han Feng: DO NOT have relevant financial relationships | Mayana Bsoul: DO NOT have relevant financial relationships | Ala' Assaf: DO NOT have relevant financial relationships | Nour Chouman: No Answer | Francisco Tirado Polo: DO NOT have relevant financial relationships | Yingshuo Liu: DO NOT have relevant financial relationships | Yishi Jia: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

One and Done or Three-Peat? Understanding, Predicting and Preventing Recurrence in AFib Ablation

Monday, 11/18/2024 , 12:50PM - 02:05PM

Moderated Digital Poster Session

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