Scientific Sessions 2024  /  Temporary and Durable Mechanical Circulatory Support in Heart Failure Management  /  Impact of Heart Failure Readmission in HeartMate 3 LVAD Recipients
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American Heart Association

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Final ID: MDP854

Impact of Heart Failure Readmission in HeartMate 3 LVAD Recipients

Abstract Body (Do not enter title and authors here):
Background: Despite the survival benefit of durable left ventricular assist device (LVAD) therapy in patients with advanced heart failure, hospital readmissions due to heart failure (HF) remain a significant morbidity and determinant of quality of life.

Objective: This study aimed to characterize patients with and without a HF readmission and determine its clinical impact following HeartMate 3 (HM3) LVAD implantation.

Methods/Approach: A single-center retrospective analysis was performed of patients who underwent HM3 LVAD implantation from January 1, 2015 to December 31, 2021. Patients with and without a HF readmission were compared based on 53 variables. Cox proportional hazard model was performed to investigate the association between HF readmission and survival.

Results: A total of 273 patients underwent HM3 implantation. The average implant age was 58 years, 75% were men, and 78% were Black patients. Of the 273 patients, 78 (29%) had a HF readmission and 58 (74%) occurred within the first year following implant. Predictors of a HF readmission include pre-implant diabetes mellitus (HR 1.96; 95% CI, 1.2-3.2; p=0.007), pre-implant body mass index (HR 1.05; 95% CI, 1.02-1.09; p<0.001) and post implant BUN (HR 1.02; 95% CI, 1-1.04; p=0.018). There was no significant difference in survival in patients with and without a HF readmission (multivariate-adjusted HR 1.44; 95% CI, 0.87-2.37; p=0.153; Figure) at long-term follow up (6 years).

Conclusion: Readmissions for HF remain an opportunity for improvement in the care of HM3 LVAD patients. However, a HF readmission was not associated with an increased risk of death. Addressing comorbid conditions and identifying strategies to optimize LVAD and HF management in this high-risk cohort warrant further exploration to improve clinical outcomes.
  • Tejada Frisancho, Flavia  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Balsara, Keki  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Sheikh, Farooq  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Lam, Phillip  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Li, Zhi  ( Georgetown University School of Medicine , Washington , District of Columbia , United States )
  • Shaban, Liza  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Kadakkal, Ajay  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Hockstein, Michael  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Gupta, Richa  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Glocker, Shawn  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Pinilla-vera, Miguel  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
  • Rodrigo, Maria  ( MedStar Washington Hospital Center , Washington DC , District of Columbia , United States )
    • Author Disclosures:
    Flavia Tejada Frisancho: DO NOT have relevant financial relationships | Keki Balsara: No Answer | Farooq Sheikh: DO have relevant financial relationships ; Consultant:Abbott:Active (exists now) ; Research Funding (PI or named investigator):Alexion:Active (exists now) ; Research Funding (PI or named investigator):Akcea:Active (exists now) ; Research Funding (PI or named investigator):Alnylam:Active (exists now) ; Consultant:Alnylam:Active (exists now) | Phillip Lam: No Answer | Zhi Li: DO NOT have relevant financial relationships | Liza Shaban: DO NOT have relevant financial relationships | Ajay Kadakkal: No Answer | Michael Hockstein: No Answer | Richa Gupta: DO have relevant financial relationships ; Speaker:CVRx:Active (exists now) | Shawn Glocker: No Answer | Miguel Pinilla-Vera: DO NOT have relevant financial relationships | Maria Rodrigo: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Temporary and Durable Mechanical Circulatory Support in Heart Failure Management

Sunday, 11/17/2024 , 09:30AM - 10:45AM

Moderated Digital Poster Session

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