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American Heart Association

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Final ID: Sa2042

MRI-Measured Myocardial Strain as a Predictor of Clinical Outcomes in Systemic RV.

Abstract Body (Do not enter title and authors here): Background: Systemic RV dysfunction is a common concern in patients with d-Transposition of the great arteries (d-TGA) after atrial switch and congenitally corrected TGA (ccTGA). We investigated myocardial strain on MRI to predict clinical outcomes.
Methods: We analyzed 50 MRI studies (33 d-TGA with atrial switch, 17 ccTGA, mean age 42 ± 13 years) after excluding studies with fewer than 30 phases or incomplete images. Feature-tracking of SSFP cine was retrospectively utilized to quantify radial, circumferential, and longitudinal strain in both 2 and 3 dimensions. Physiological class (PC) was determined by clinicians according to the 2018 AHA/ACC guidelines. Clinical events (e.g., change in PC, initiation or escalation of diuretics, mortality, arrhythmias, heart failure hospitalization) over a 5-year period were obtained through chart review.
Results: Deterioration of PC was significantly associated with worsening of all strain measures (p ≤0.05 for each) except 3D global radial strain. RV ejection fraction (EF) was also significant (p ≤0.05). Importantly, in patients experiencing new clinical events within 5 years, baseline absolute values of global longitudinal strain (2D and 3D) were significantly worse (p ≤0.05 for both), whereas RVEF was not (Figure).
Conclusion: MRI-measured global longitudinal strain holds promise as a prognostic indicator for clinical outcomes in adults with systemic RV dysfunction. These findings underscore its potential utility in risk stratification and guiding management decisions.
  • Kajimoto, Hidemi  ( OHSU , Portland , Oregon , United States )
  • Broberg, Craig  ( OHSU , Portland , Oregon , United States )
  • Author Disclosures:
    Hidemi Kajimoto: DO NOT have relevant financial relationships | Craig Broberg: No Answer
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:

Pediatric Cardiac Care

Saturday, 11/16/2024 , 02:00PM - 03:00PM

Abstract Poster Session

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