Geographic, Gender, & Racial Trends in Mortality Due to Coronary Artery Disease in Obesity among Adults Aged 25 and Older in the United States, 1999-2020: A CDC WONDER Database Analysis
Abstract Body (Do not enter title and authors here): Background: Coronary Artery Disease (CAD) in obese population is the most common cause of mortality worldwide. This study examines the variation in cardiovascular mortality rates due to CAD in obese adults aged 25 and above from 1999 to 2020. Methods: We performed a retrospective cohort study using death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research (CDC WONDER) database from 1999 to 2020. We calculated age-adjusted mortality rates (AAMRs), annual percent change (APC), and average annual percentage change (AAPC) per 100,000 persons. The information was categorized based on year, gender, ethnicity, and geographic area. Results: Between 1999 and 2020, CAD in obesity accounted for 102,434 deaths among adults (≥25 years) in the United States. Majority of deaths occurred in medical facilities (49.0%), followed by decedents' homes (36.8%). The overall AAMR for CAD in obesity-related deaths increased from 1.5 in 1999 to 3.3 in 2020, with an AAPC of 3.46 (95% CI: 2.83 to 3.92, p < 0.000001). Men exhibited higher AAMRs compared to women (men: 2.7; women: 1.6), with significant increases for both sex. The increase was more prominent in men (AAPC: 4.34, 95% CI: 3.73 to 4.83, p < 0.000001). Racial/ethnic disparities were evident, with American Indian or Alaska Native individuals having the highest AAMR (2.9), followed by Black or African American (2.4), White (2.3), Hispanic or Latino (1.3), and Asian or Pacific Islander (0.5). All racial groups experienced an increase in AAMR from 1999 to 2020, most pronounced in American Indian or Alaska Native individuals (AAPC: 5.06, 95% CI: 2.90 to 8.64, p < 0.000001). Geographically, AAMRs ranged from 1.0 in Alabama to 4.3 in North Dakota, with the Midwestern region having the highest mortality (AAMR: 2.6). Nonmetropolitan areas exhibited higher AAMRs than metropolitan areas (nonmetropolitan: 2.8; metropolitan: 2.0). (Figure 1) Conclusion: This study highlights significant demographic disparities in mortality rates due to CAD in obesity among adults aged 25 and older. Despite an overall increase in mortality rates, the significant rise in recent years, particularly among certain racial groups and geographical regions, emphasize the need for targeted interventions and equal healthcare access to improve outcomes for affected populations.
Naveed, Muhammad Abdullah
( Dow Medical College, DUHS
, Karachi
, Pakistan
)
Alboushi Aldabagh, Mohammad
( Montefiore Medical Center
, Mamroneck
, New York
, United States
)
Ahmed, Faizan
( Ameeruddin Medical College
, Brooklyn
, New York
, United States
)
Omer Rehan, Muhammad
( Dow Medical College, DUHS
, KARACHANI
, Pakistan
)
Iqbal, Rabia
( Dow University Of Health Sciences
, Karachi
, Pakistan
)
Azeem, Bazil
( Shaheed Mohtarma Benazir Bhutto Medical College
, Karachi
, Pakistan
)
Cheema, Mustafa Sajjad
( CMH Lahore Medical College and Institute of Dentistry
, LAHORE
, Pakistan
)
Sattar, Yasar
( Icahn School of Medicine at Mount S
, QUEENA
, New York
, United States
)
Author Disclosures:
Muhammad Abdullah Naveed:DO NOT have relevant financial relationships
| Mohammad Alboushi Aldabagh:DO NOT have relevant financial relationships
| Ahila Ali:DO NOT have relevant financial relationships
| Faizan Ahmed:DO NOT have relevant financial relationships
| Muhammad Omer Rehan:DO NOT have relevant financial relationships
| Rabia Iqbal:DO NOT have relevant financial relationships
| Bazil Azeem:DO NOT have relevant financial relationships
| Mustafa Sajjad Cheema:DO NOT have relevant financial relationships
| yasar sattar:No Answer