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American Heart Association

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Final ID: MDP318

Trend, Survival, and Disparity Analysis of Heart Transplantation in a Single Large Transplant Center

Abstract Body (Do not enter title and authors here): Background
In the landscape of organ transplantation, heart transplantation stands as a life-saving procedure for patients with end-stage heart failure. Comprehensive analyses of transplant programs are imperative to optimize outcomes and understand the complexities.
Hypothesis
This study hypothesizes that an increasing trend of heart transplant service and short-term mechanical circulatory support (STMCS) is the bridge to transplant; the UNOS (United Network for Organ Sharing) guideline positively impacts STMCS utilization. Even with the standard of care, there might be a disparity in receiving care in terms of gender and race.
Goal/ Aims
By examining this center's collective experience, this research provides valuable insights into the evolving landscape of heart transplantation, ultimately contributing to advancements in patient care and transplant policy.

Methods
This retrospective cohort study includes heart transplant patients in a single large transplant center. For statistical analysis, Cox regression, Mann-Whitney test, Kruskal Wallis, and Chi-Square test were used in IBM SPSS 25.

Result
Trends
This retrospective study covering 2010 to 2022 comprehensively analyzed 1513 heart transplant patients. The cohort consisted of 1071 (70.78%) males and 442 (29.21%) females, 31.9% were bridged through STMCS. 76.7% of Caucasian and 16.1% were African American.The mean utilization of STMCS was 20.08% before the UNOS policy change, increasing to 53.81% after that (p < 0.001).
Disparity Analysis
There was a statistically significant difference in STMCS utilization between white and black patients (p= 0.008) but no difference in between obese and non-obese cohorts (P=0.362).Wait time was similar among the genders (p=0.161) and different races (p=0.302).
Survival Analysis
There is a significant survival discrepancy between patients bridged through MCS and those without STMCS(p< 0.001). However, yearly trend analysis showed an evolving survival trajectory favoring STMCS users. There are statistically significant survival differences among whites and blacks (P =0.008) but similar among the genders (p=0.589).

Summary
The study reveals significant changes in the trend of transplants regarding STMCS utilization since the UNOS guideline. There are substantial differences in survival between STMCS vs. non-STMCS groups and among the races.There was a significant difference in STMCS utilization among the races.
  • Kc, Anil  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Sanghavi, Devang  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Bhattacharyya, Anirban  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Patel, Parag  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Pham, Si  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Guru, Pramod  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Chaudhary, Sanjay  ( Mayo Clinic Florida , Jacksonville , Florida , United States )
  • Author Disclosures:
    ANIL KC: DO NOT have relevant financial relationships | Devang Sanghavi: DO NOT have relevant financial relationships | Anirban Bhattacharyya: DO NOT have relevant financial relationships | Parag Patel: DO NOT have relevant financial relationships | Si Pham: No Answer | Pramod Guru: DO NOT have relevant financial relationships | Sanjay Chaudhary: DO NOT have relevant financial relationships
Meeting Info:

Scientific Sessions 2024

2024

Chicago, Illinois

Session Info:
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